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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2007 Volume 17 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2007 Volume 17 Issue 1

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Article

Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma

  • Authors:
    • So-Yeon Park
    • Seoung-Ae Lee
    • In-Hee Han
    • Byong-Chul Yoo
    • Seung-Hoon Lee
    • Jo-Yong Park
    • In-Ho Cha
    • Jin Kim
    • Sung-Weon Choi

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, College of Medicine, Seoul National University, Seoul, Korea
  • Pages: 81-87
    |
    Published online on: January 1, 2007
       https://doi.org/10.3892/or.17.1.81
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Abstract

The multifunctional G-protein-coupled metabotropic glutamate receptor (mGluR) family comprises eight subtypes, some of which participate in tumorigenesis. The purpose of this study was to evaluate mGluR5 expression in oral squamous cell carcinoma (SCC) tissues and oral cancer cell lines. We also investigated the prognostic significance of mGluR5 and its functional importance in the migration, invasion, and adhesion of oral cancer cells. We evaluated the expression of mGluR5 in samples from 131 oral SCC patients and in several oral cancer cell lines by immunohistochemistry and RT-PCR. We observed varying levels of mGluR5 in human oral SCC tissues and cancer cell lines. There was a significant association between strong mGluR5 immunoreactivity and overall survival (P=0.0109). The functional significance of the expression of mGluR5 in oral cancer cells was then investigated in HSC3 oral tongue cancer cells. An mGluR5 agonist, DHPG increased tumor cell migration, invasion, and adhesion in HSC3 cells (P<0.05). This was reversed by the mGluR5 antagonist MPEP. Our results strongly suggest that mGluR5 is a new prognostic marker and contributes to tumor cell migration and invasion in oral cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Park S, Lee S, Han I, Yoo B, Lee S, Park J, Cha I, Kim J and Choi S: Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma. Oncol Rep 17: 81-87, 2007.
APA
Park, S., Lee, S., Han, I., Yoo, B., Lee, S., Park, J. ... Choi, S. (2007). Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma. Oncology Reports, 17, 81-87. https://doi.org/10.3892/or.17.1.81
MLA
Park, S., Lee, S., Han, I., Yoo, B., Lee, S., Park, J., Cha, I., Kim, J., Choi, S."Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma". Oncology Reports 17.1 (2007): 81-87.
Chicago
Park, S., Lee, S., Han, I., Yoo, B., Lee, S., Park, J., Cha, I., Kim, J., Choi, S."Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma". Oncology Reports 17, no. 1 (2007): 81-87. https://doi.org/10.3892/or.17.1.81
Copy and paste a formatted citation
x
Spandidos Publications style
Park S, Lee S, Han I, Yoo B, Lee S, Park J, Cha I, Kim J and Choi S: Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma. Oncol Rep 17: 81-87, 2007.
APA
Park, S., Lee, S., Han, I., Yoo, B., Lee, S., Park, J. ... Choi, S. (2007). Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma. Oncology Reports, 17, 81-87. https://doi.org/10.3892/or.17.1.81
MLA
Park, S., Lee, S., Han, I., Yoo, B., Lee, S., Park, J., Cha, I., Kim, J., Choi, S."Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma". Oncology Reports 17.1 (2007): 81-87.
Chicago
Park, S., Lee, S., Han, I., Yoo, B., Lee, S., Park, J., Cha, I., Kim, J., Choi, S."Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma". Oncology Reports 17, no. 1 (2007): 81-87. https://doi.org/10.3892/or.17.1.81
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