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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2007 Volume 17 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2007 Volume 17 Issue 2

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Article

Gefitinib induces premature senescence in non-small cell lung cancer cells with or without EGFR gene mutation

  • Authors:
    • Katsuyuki Hotta
    • Masahiro Tabata
    • Katsuyuki Kiura
    • Toshiyuki Kozuki
    • Akiko Hisamoto
    • Hideki Katayama
    • Nagio Takigawa
    • Nobukazu Fujimoto
    • Keiichi Fujiwara
    • Hiroshi Ueoka
    • Mitsune Tanimoto

  • View Affiliations / Copyright

    Affiliations: Department of Medicine II, Okayama University Medical School, Okayama 700-8558, Japan. khotta@md.okayama-u.ac.jp
  • Pages: 313-317
    |
    Published online on: February 1, 2007
       https://doi.org/10.3892/or.17.2.313
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Abstract

Despite its tremendous antitumor effect in a subset of patients with non-small cell lung cancer (NSCLC), the exact mechanism of gefitinib-induced cell death has not been fully determined. In this study, forms of cell death in various NSCLC cell lines after gefitinib exposure was analyzed to elucidate the cell death mechanism of gefitinib. Though higher concentration of gefitinib (10 µM) induced extensive apoptosis in two cell lines (EGFR-mutated PC-9 cells and EGFR wild- type EBC-2/R cells), clinically relevant concentrations of gefitinib (1 µM) induced prominent premature senescence instead of apoptosis in these cells. This induction of senescence was preceded by immediate increase of p16INK4A, p21WAF1/Cip1 and p27Kip1 levels and subsequent G1 cell cycle arrest. These phenomena were not observed in gefitinib-resistant (RERF-LC-MS) cells. Additionally, ex vivo exposure to gefitinib induced senescence in short-term cultured tumor cells that were obtained from malignant pleural effusion of a patient with NSCLC, whose tumor was later revealed to be clinically sensitive to gefitinib. Our results indicate that senescence might be a major anti-tumor mechanism of gefitinib in these NSCLC cells regardless of the EGFR gene mutation status.

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Copy and paste a formatted citation
Spandidos Publications style
Hotta K, Tabata M, Kiura K, Kozuki T, Hisamoto A, Katayama H, Takigawa N, Fujimoto N, Fujiwara K, Ueoka H, Ueoka H, et al: Gefitinib induces premature senescence in non-small cell lung cancer cells with or without EGFR gene mutation. Oncol Rep 17: 313-317, 2007.
APA
Hotta, K., Tabata, M., Kiura, K., Kozuki, T., Hisamoto, A., Katayama, H. ... Tanimoto, M. (2007). Gefitinib induces premature senescence in non-small cell lung cancer cells with or without EGFR gene mutation. Oncology Reports, 17, 313-317. https://doi.org/10.3892/or.17.2.313
MLA
Hotta, K., Tabata, M., Kiura, K., Kozuki, T., Hisamoto, A., Katayama, H., Takigawa, N., Fujimoto, N., Fujiwara, K., Ueoka, H., Tanimoto, M."Gefitinib induces premature senescence in non-small cell lung cancer cells with or without EGFR gene mutation". Oncology Reports 17.2 (2007): 313-317.
Chicago
Hotta, K., Tabata, M., Kiura, K., Kozuki, T., Hisamoto, A., Katayama, H., Takigawa, N., Fujimoto, N., Fujiwara, K., Ueoka, H., Tanimoto, M."Gefitinib induces premature senescence in non-small cell lung cancer cells with or without EGFR gene mutation". Oncology Reports 17, no. 2 (2007): 313-317. https://doi.org/10.3892/or.17.2.313
Copy and paste a formatted citation
x
Spandidos Publications style
Hotta K, Tabata M, Kiura K, Kozuki T, Hisamoto A, Katayama H, Takigawa N, Fujimoto N, Fujiwara K, Ueoka H, Ueoka H, et al: Gefitinib induces premature senescence in non-small cell lung cancer cells with or without EGFR gene mutation. Oncol Rep 17: 313-317, 2007.
APA
Hotta, K., Tabata, M., Kiura, K., Kozuki, T., Hisamoto, A., Katayama, H. ... Tanimoto, M. (2007). Gefitinib induces premature senescence in non-small cell lung cancer cells with or without EGFR gene mutation. Oncology Reports, 17, 313-317. https://doi.org/10.3892/or.17.2.313
MLA
Hotta, K., Tabata, M., Kiura, K., Kozuki, T., Hisamoto, A., Katayama, H., Takigawa, N., Fujimoto, N., Fujiwara, K., Ueoka, H., Tanimoto, M."Gefitinib induces premature senescence in non-small cell lung cancer cells with or without EGFR gene mutation". Oncology Reports 17.2 (2007): 313-317.
Chicago
Hotta, K., Tabata, M., Kiura, K., Kozuki, T., Hisamoto, A., Katayama, H., Takigawa, N., Fujimoto, N., Fujiwara, K., Ueoka, H., Tanimoto, M."Gefitinib induces premature senescence in non-small cell lung cancer cells with or without EGFR gene mutation". Oncology Reports 17, no. 2 (2007): 313-317. https://doi.org/10.3892/or.17.2.313
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