Expression of protease activated receptor-2 related to angiogenesis in tumor advancement of uterine endometrial cancers

  • Authors:
    • Israt Jahan
    • Jiro Fujimoto
    • Syed Mahfuzul Alam
    • Eriko Sato
    • Hideki Sakaguchi
    • Teruhiko Tamaya
  • View Affiliations

  • Published online on: February 1, 2007     https://doi.org/10.3892/or.17.2.345
  • Pages: 345-350
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Abstract

Protease activated receptor-2 (PAR-2) is the second member of a novel family of G-protein coupled seven-transmembrane domain receptors. PAR-2 has been reported to be expressed in various tumors and play a vital role in the regulation of cancer cell growth. The purpose of this study was to clarify the roles of PAR-2 in the angiogenic pathway in uterine endometrial cancers. PAR-2 expression was analyzed in 61 uterine endometrial cancer and 15 normal endometrium tissue specimens. PAR-2 histoscores and mRNA levels were determined by immunohistochemistry and real-time RT-PCR, respectively. Microvessel counts were determined by immunohistochemistry for CD31 and factor VIII-related antigen. The localization of PAR-2 was dominant in the cancer cells of endometrial cancer tissues of all cases studied. PAR-2 histoscores highly correlated with PAR-2 mRNA levels in the same tissues (r=0.87, p<0.001). PAR-2 histoscores and mRNA levels both significantly increased in uterine endometrial cancers with clinical stages (I< II< III, p<0.001), dedifferentiation (G1< G2< G3, p<0.001) and myometrial invasion (A< B, p<0.001; B< C, p<0.05) in comparison to normal endometria. There were significant correlations between PAR-2 histoscores and mRNA levels with microvessel counts in uterine endometrial cancers. PAR-2 was upregulated during uterine endometrial cancer progression with dedifferentiation and myometrial invasion. Therefore, PAR-2 might work on tumor advancement of uterine endometrial cancers via angiogenic activity.

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February 2007
Volume 17 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jahan I, Fujimoto J, Alam SM, Sato E, Sakaguchi H and Tamaya T: Expression of protease activated receptor-2 related to angiogenesis in tumor advancement of uterine endometrial cancers. Oncol Rep 17: 345-350, 2007.
APA
Jahan, I., Fujimoto, J., Alam, S.M., Sato, E., Sakaguchi, H., & Tamaya, T. (2007). Expression of protease activated receptor-2 related to angiogenesis in tumor advancement of uterine endometrial cancers. Oncology Reports, 17, 345-350. https://doi.org/10.3892/or.17.2.345
MLA
Jahan, I., Fujimoto, J., Alam, S. M., Sato, E., Sakaguchi, H., Tamaya, T."Expression of protease activated receptor-2 related to angiogenesis in tumor advancement of uterine endometrial cancers". Oncology Reports 17.2 (2007): 345-350.
Chicago
Jahan, I., Fujimoto, J., Alam, S. M., Sato, E., Sakaguchi, H., Tamaya, T."Expression of protease activated receptor-2 related to angiogenesis in tumor advancement of uterine endometrial cancers". Oncology Reports 17, no. 2 (2007): 345-350. https://doi.org/10.3892/or.17.2.345