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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2007 Volume 17 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Apoptosis induced by lycorine in KM3 cells is associated with the G0/G1 cell cycle arrest

  • Authors:
    • Yan Li
    • Jing Liu
    • Li-Jun Tang
    • Yi-Wu Shi
    • Wei Ren
    • Wei-Xin Hu

  • View Affiliations / Copyright

    Affiliations: olecular Biology Research Center, School of Biological Science and Technology, Central South University, Hunan 410078, P.R. China
  • Pages: 377-384
    |
    Published online on: February 1, 2007
       https://doi.org/10.3892/or.17.2.377
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Abstract

Lycorine is a natural anti-tumor alkaloid extracted from Amaryllidaceae and has various biological effects on malignant cells. The present study explores the effects of lycorine on the human multiple meyloma cell line, KM3, and the possible mechanisms of these effects. An MTT assay showed that lycorine had significant inhibitory activity on KM3 cells. The growth rates of the KM3 cells exposed to lycorine evidently slowed down. Cell fluorescent apoptotic morphological changes, DNA degradation fragments, and a sub-G1 peak were detected, indicating the occurrence of cell apoptosis after lycorine treatment. Furthermore, the release of mitochondrial cytochrome c, the augmentation of Bax with the attenuation of Bcl-2, and the activation of caspase-9, -8, and -3 were also detected, suggesting that the mitochondrial pathway and the death acceptor pathway were also involved. The results also showed that lycorine was able to block the cell cycle at the G0/G1 phase through the downregulation of both cyclin D1 and CDK4. In summary, lycorine can suppress the proliferation of KM3 cells and reduce cell survival by arresting cell cycle progression as well as inducing cell apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Liu J, Tang L, Shi Y, Ren W and Hu W: Apoptosis induced by lycorine in KM3 cells is associated with the G0/G1 cell cycle arrest. Oncol Rep 17: 377-384, 2007.
APA
Li, Y., Liu, J., Tang, L., Shi, Y., Ren, W., & Hu, W. (2007). Apoptosis induced by lycorine in KM3 cells is associated with the G0/G1 cell cycle arrest. Oncology Reports, 17, 377-384. https://doi.org/10.3892/or.17.2.377
MLA
Li, Y., Liu, J., Tang, L., Shi, Y., Ren, W., Hu, W."Apoptosis induced by lycorine in KM3 cells is associated with the G0/G1 cell cycle arrest". Oncology Reports 17.2 (2007): 377-384.
Chicago
Li, Y., Liu, J., Tang, L., Shi, Y., Ren, W., Hu, W."Apoptosis induced by lycorine in KM3 cells is associated with the G0/G1 cell cycle arrest". Oncology Reports 17, no. 2 (2007): 377-384. https://doi.org/10.3892/or.17.2.377
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Liu J, Tang L, Shi Y, Ren W and Hu W: Apoptosis induced by lycorine in KM3 cells is associated with the G0/G1 cell cycle arrest. Oncol Rep 17: 377-384, 2007.
APA
Li, Y., Liu, J., Tang, L., Shi, Y., Ren, W., & Hu, W. (2007). Apoptosis induced by lycorine in KM3 cells is associated with the G0/G1 cell cycle arrest. Oncology Reports, 17, 377-384. https://doi.org/10.3892/or.17.2.377
MLA
Li, Y., Liu, J., Tang, L., Shi, Y., Ren, W., Hu, W."Apoptosis induced by lycorine in KM3 cells is associated with the G0/G1 cell cycle arrest". Oncology Reports 17.2 (2007): 377-384.
Chicago
Li, Y., Liu, J., Tang, L., Shi, Y., Ren, W., Hu, W."Apoptosis induced by lycorine in KM3 cells is associated with the G0/G1 cell cycle arrest". Oncology Reports 17, no. 2 (2007): 377-384. https://doi.org/10.3892/or.17.2.377
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