Expression of factors involved in regulation of DNA mismatch repair- and apoptosis pathways in ovarian cancer patients

  • Authors:
    • Verena Materna
    • Pawel Surowiak
    • Ewa Markwitz
    • Marek Spaczynski
    • Malgorzata Drag-Zalesinska
    • Maciej Zabel
    • Hermann Lage
  • View Affiliations

  • Published online on: March 1, 2007     https://doi.org/10.3892/or.17.3.505
  • Pages:505-516
0

Abstract

A major obstacle in treatment of ovarian cancer is intrinsic or acquired drug resistance causing failure of chemotherapy followed by a poor clinical outcome. Drug resistance of ovarian carcinoma can be caused by dysregulation of cellular factors involved in regulation of apoptosis and DNA repair pathways. In this study, 73 ovarian carcinoma specimens obtained before and after chemotherapy were analysed by immunohistochemistry for expression of seven proteins playing an important role in regulation of DNA mismatch repair and apoptosis. The prognostic significance of these proteins in the meaning of overall and progression-free survival was evaluated in univariate and multivariate analysis. Bcl-xL, hMSH2, caspase-3, p21 and p53 displayed prognostic importance in univariate analysis. Furthermore, it was demonstrated that caspase-3 and p21 were also independent prognostic markers for both, overall and progression-free survival. In conclusion, these data indicate that analysis of proteins involved in DNA mismatch repair and apoptosis can be useful for prediction of clinical outcome in ovarian carcinoma patients.

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March 2007
Volume 17 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

2016 Impact Factor: 2.662
Ranked #31/217 Oncology
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APA
Materna, V., Surowiak, P., Markwitz, E., Spaczynski, M., Drag-Zalesinska, M., Zabel, M., & Lage, H. (2007). Expression of factors involved in regulation of DNA mismatch repair- and apoptosis pathways in ovarian cancer patients. Oncology Reports, 17, 505-516. https://doi.org/10.3892/or.17.3.505
MLA
Materna, V., Surowiak, P., Markwitz, E., Spaczynski, M., Drag-Zalesinska, M., Zabel, M., Lage, H."Expression of factors involved in regulation of DNA mismatch repair- and apoptosis pathways in ovarian cancer patients". Oncology Reports 17.3 (2007): 505-516.
Chicago
Materna, V., Surowiak, P., Markwitz, E., Spaczynski, M., Drag-Zalesinska, M., Zabel, M., Lage, H."Expression of factors involved in regulation of DNA mismatch repair- and apoptosis pathways in ovarian cancer patients". Oncology Reports 17, no. 3 (2007): 505-516. https://doi.org/10.3892/or.17.3.505