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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2007 Volume 17 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan

  • Authors:
    • Eva Martinez-Balibrea
    • Jose Luis Manzano
    • Anna Martinez-Cardus
    • Teresa Moran
    • Beatriz Cirauqui
    • Silvia Catot
    • Miguel Taron
    • Albert Abad

  • View Affiliations / Copyright

    Affiliations: edical Oncology Service, Institut Catala Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona 08916, Barcelona, Spain
  • Pages: 637-645
    |
    Published online on: March 1, 2007
       https://doi.org/10.3892/or.17.3.637
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Abstract

The aim of this study was to investigate the influence of combining thymidylate synthase (TS), X-ray cross complementing factor 1 (XRCC1) and uridine diphosphate glucoronosyltransferase (UGT1A1∗28) polymorphism genotypes in response rate and time to progression (TTP) in metastatic colorectal cancer patients treated with 5-fluorouracil (5-FU) plus irinotecan or oxaliplatin (OXA). PCR, RFLP, allelic discrimination and direct sequencing were performed to elucidate TS, XRCC1 and UGT1A1∗28 genotypes in blood from 71 patients. Patients with a number of favourable genotypes (NFG) ≥1 had a lower progression rate and a better TTP than patients with NFG=0 (log-rank p<0.03). In the OXA + 5-FU group, patients with the TS 5' single nucleotide polymorphism and/or XRCC1 genotypes favourable to treatment had a better TTP (log-rank p=0.02). The TS 5' tandem repeat polymorphism and the NFG were independent prognostic factors in the Cox-based multivariate analysis (p<0.03). These results confirm the influence on patient out-come of these genetic polymorphisms and the possibility of studying them together to predict the outcome in first-line treated colorectal cancer patients.

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Copy and paste a formatted citation
Spandidos Publications style
Martinez-Balibrea E, Manzano JL, Martinez-Cardus A, Moran T, Cirauqui B, Catot S, Taron M and Abad A: Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan. Oncol Rep 17: 637-645, 2007.
APA
Martinez-Balibrea, E., Manzano, J.L., Martinez-Cardus, A., Moran, T., Cirauqui, B., Catot, S. ... Abad, A. (2007). Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan. Oncology Reports, 17, 637-645. https://doi.org/10.3892/or.17.3.637
MLA
Martinez-Balibrea, E., Manzano, J. L., Martinez-Cardus, A., Moran, T., Cirauqui, B., Catot, S., Taron, M., Abad, A."Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan". Oncology Reports 17.3 (2007): 637-645.
Chicago
Martinez-Balibrea, E., Manzano, J. L., Martinez-Cardus, A., Moran, T., Cirauqui, B., Catot, S., Taron, M., Abad, A."Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan". Oncology Reports 17, no. 3 (2007): 637-645. https://doi.org/10.3892/or.17.3.637
Copy and paste a formatted citation
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Spandidos Publications style
Martinez-Balibrea E, Manzano JL, Martinez-Cardus A, Moran T, Cirauqui B, Catot S, Taron M and Abad A: Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan. Oncol Rep 17: 637-645, 2007.
APA
Martinez-Balibrea, E., Manzano, J.L., Martinez-Cardus, A., Moran, T., Cirauqui, B., Catot, S. ... Abad, A. (2007). Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan. Oncology Reports, 17, 637-645. https://doi.org/10.3892/or.17.3.637
MLA
Martinez-Balibrea, E., Manzano, J. L., Martinez-Cardus, A., Moran, T., Cirauqui, B., Catot, S., Taron, M., Abad, A."Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan". Oncology Reports 17.3 (2007): 637-645.
Chicago
Martinez-Balibrea, E., Manzano, J. L., Martinez-Cardus, A., Moran, T., Cirauqui, B., Catot, S., Taron, M., Abad, A."Combined analysis of genetic polymorphisms in thymidylate synthase, uridine diphosphate glucoronosyltransferase and X-ray cross complementing factor 1 genes as a prognostic factor in advanced colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan". Oncology Reports 17, no. 3 (2007): 637-645. https://doi.org/10.3892/or.17.3.637
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