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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2007 Volume 17 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2007 Volume 17 Issue 3

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Article

Regulation of the HIF-1α stability by histone deacetylases

  • Authors:
    • Se-Hee Kim
    • Joo-Won Jeong
    • Jeong Ae Park
    • Ji-Won Lee
    • Ji Hae Seo
    • Bo-Kyung Jung
    • Moon-Kyoung Bae
    • Kyu-Won Kim

  • View Affiliations / Copyright

    Affiliations: NeuroVascular Coordination Research Center, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea
  • Pages: 647-651
    |
    Published online on: March 1, 2007
       https://doi.org/10.3892/or.17.3.647
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Abstract

Histone deacetylase inhibitors (HDACIs) are currently in clinical trials partly due to their potent anti-angiogenic effects. However, the detailed mechanism of their action is unclear. Here, we observed that several HDACIs (TSA, SB, Apicidin, and VPA) dramatically decreased HIF-1α protein level and transcriptional activity of HIF-1 in human and mouse tumor cell lines. Furthermore, class I HDACs, HDAC1 and 3 enhanced HIF-1α stability and HIF-1 transactivation function in hypoxic conditions. In addition, immunoprecipitation and in vitro binding assays revealed that HDAC1 and 3 directly bind to the oxygen-dependent degradation domain of HIF-1α. Collectively, these results suggest that HDAC1 and 3 are considered as a positive regulator of HIF-1α stability via direct interaction and may play an important role in HIF-1-induced tumor angiogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Kim S, Jeong J, Park JA, Lee J, Seo JH, Jung B, Bae M and Kim K: Regulation of the HIF-1α stability by histone deacetylases. Oncol Rep 17: 647-651, 2007.
APA
Kim, S., Jeong, J., Park, J.A., Lee, J., Seo, J.H., Jung, B. ... Kim, K. (2007). Regulation of the HIF-1α stability by histone deacetylases. Oncology Reports, 17, 647-651. https://doi.org/10.3892/or.17.3.647
MLA
Kim, S., Jeong, J., Park, J. A., Lee, J., Seo, J. H., Jung, B., Bae, M., Kim, K."Regulation of the HIF-1α stability by histone deacetylases". Oncology Reports 17.3 (2007): 647-651.
Chicago
Kim, S., Jeong, J., Park, J. A., Lee, J., Seo, J. H., Jung, B., Bae, M., Kim, K."Regulation of the HIF-1α stability by histone deacetylases". Oncology Reports 17, no. 3 (2007): 647-651. https://doi.org/10.3892/or.17.3.647
Copy and paste a formatted citation
x
Spandidos Publications style
Kim S, Jeong J, Park JA, Lee J, Seo JH, Jung B, Bae M and Kim K: Regulation of the HIF-1α stability by histone deacetylases. Oncol Rep 17: 647-651, 2007.
APA
Kim, S., Jeong, J., Park, J.A., Lee, J., Seo, J.H., Jung, B. ... Kim, K. (2007). Regulation of the HIF-1α stability by histone deacetylases. Oncology Reports, 17, 647-651. https://doi.org/10.3892/or.17.3.647
MLA
Kim, S., Jeong, J., Park, J. A., Lee, J., Seo, J. H., Jung, B., Bae, M., Kim, K."Regulation of the HIF-1α stability by histone deacetylases". Oncology Reports 17.3 (2007): 647-651.
Chicago
Kim, S., Jeong, J., Park, J. A., Lee, J., Seo, J. H., Jung, B., Bae, M., Kim, K."Regulation of the HIF-1α stability by histone deacetylases". Oncology Reports 17, no. 3 (2007): 647-651. https://doi.org/10.3892/or.17.3.647
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