Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder: Immunohistochemical analysis of mucin profile and CD10

  • Authors:
    • Shigenori Nagata
    • Yoichi Ajioka
    • Ken Nishikura
    • Gen Watanabe
    • Takahiro Inoue
    • Koji Yamaguchi
    • Hidenobu Watanabe
    • Masao Tanaka
    • Masazumi Tsuneyoshi
  • View Affiliations

  • Published online on: April 1, 2007     https://doi.org/10.3892/or.17.4.721
  • Pages: 721-729
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Abstract

Pyloric-gland type adenoma of the gallbladder is formed by proliferation of glands resembling pyloric glands, morphologically. No previous report has described the cellular phenotype and differentiation of pyloric-gland type adenoma of the gallbladder, using CD10 as a marker of proper biliary phenotype. Immunostainings were performed for mucin markers such as MUC5AC, human gastric mucin (HGM) for gastric foveolar type epithelium, MUC6, M-GGMC-1 for pyloric-gland type and MUC2 for intestinal goblet-cell type, and for CD10 as a proper biliary type marker on 58 pyloric-gland type adenomas of the gallbladder, as well as for p53, Ki-67 and CDX2. The percentage (X) of reactive cells in relation to the total number of tumor cells was estimated semi-quantitatively, and divided into four categories: X=0% (negative), 0%

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April 2007
Volume 17 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Nagata S, Ajioka Y, Nishikura K, Watanabe G, Inoue T, Yamaguchi K, Watanabe H, Tanaka M and Tsuneyoshi M: Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder: Immunohistochemical analysis of mucin profile and CD10. Oncol Rep 17: 721-729, 2007
APA
Nagata, S., Ajioka, Y., Nishikura, K., Watanabe, G., Inoue, T., Yamaguchi, K. ... Tsuneyoshi, M. (2007). Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder: Immunohistochemical analysis of mucin profile and CD10. Oncology Reports, 17, 721-729. https://doi.org/10.3892/or.17.4.721
MLA
Nagata, S., Ajioka, Y., Nishikura, K., Watanabe, G., Inoue, T., Yamaguchi, K., Watanabe, H., Tanaka, M., Tsuneyoshi, M."Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder: Immunohistochemical analysis of mucin profile and CD10". Oncology Reports 17.4 (2007): 721-729.
Chicago
Nagata, S., Ajioka, Y., Nishikura, K., Watanabe, G., Inoue, T., Yamaguchi, K., Watanabe, H., Tanaka, M., Tsuneyoshi, M."Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder: Immunohistochemical analysis of mucin profile and CD10". Oncology Reports 17, no. 4 (2007): 721-729. https://doi.org/10.3892/or.17.4.721