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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2007 Volume 17 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Failure of apoptosis and activation on NFκB by celecoxib and aspirin in lung cancer cell lines

  • Authors:
    • Angela Gradilone
    • Ida Silvestri
    • Susanna Scarpa
    • Stefania Morrone
    • Orietta Gandini
    • Fabio M. Pulcinelli
    • Walter Gianni
    • Luigi Frati
    • Anna Maria Aglianò
    • Paola Gazzaniga

  • View Affiliations / Copyright

    Affiliations: Department of Experimental Medicine and Pathology, University of the Study of Rome ‘La Sapienza’, 00161 Rome, Italy
  • Pages: 823-828
    |
    Published online on: April 1, 2007
       https://doi.org/10.3892/or.17.4.823
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Abstract

Recent studies have demonstrated that antineoplastic activity of Cox-2 inhibitors may depend on targets other than Cox: among those, nuclear factor κB (NFκB) seems the most promising. Although preclinical studies have suggested that aspirin and Cox-2 inhibitors may influence the progression of lung cancer, the molecular mechanisms of these protective effects in this tumor type has not been fully elucidated. We investigated the effects of celecoxib and aspirin in the induction of apoptosis and in the ability to activate NFκB in three non-small cell lung cancer cell lines. Apoptosis was evaluated by FACS, caspase activation assay and expression of apoptosis-related genes by RT-PCR, while NFκB activation was assessed by immunofluorescence. No apoptotic response was observed after treatment with both high and low dose of celecoxib. Nevertheless, celecoxib at both concentrations induced a strong NFκB activation, with increased expression of NFκB-dependent genes, such as bcl-2, bcl-XL and survivin. Similarly, aspirin at both concentrations did not induce any apoptotic response, but activated NFκB in a dose-dependent manner. This study supports the hypothesis that NFκB activation is an important effect of NSAIDs in lung cancer, leading to apoptosis resistance. This effect of both aspirin and celecoxib may be considered undesirable in lung cancer chemoprevention.

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Copy and paste a formatted citation
Spandidos Publications style
Gradilone A, Silvestri I, Scarpa S, Morrone S, Gandini O, Pulcinelli FM, Gianni W, Frati L, Aglianò AM, Gazzaniga P, Gazzaniga P, et al: Failure of apoptosis and activation on NFκB by celecoxib and aspirin in lung cancer cell lines. Oncol Rep 17: 823-828, 2007.
APA
Gradilone, A., Silvestri, I., Scarpa, S., Morrone, S., Gandini, O., Pulcinelli, F.M. ... Gazzaniga, P. (2007). Failure of apoptosis and activation on NFκB by celecoxib and aspirin in lung cancer cell lines. Oncology Reports, 17, 823-828. https://doi.org/10.3892/or.17.4.823
MLA
Gradilone, A., Silvestri, I., Scarpa, S., Morrone, S., Gandini, O., Pulcinelli, F. M., Gianni, W., Frati, L., Aglianò, A. M., Gazzaniga, P."Failure of apoptosis and activation on NFκB by celecoxib and aspirin in lung cancer cell lines". Oncology Reports 17.4 (2007): 823-828.
Chicago
Gradilone, A., Silvestri, I., Scarpa, S., Morrone, S., Gandini, O., Pulcinelli, F. M., Gianni, W., Frati, L., Aglianò, A. M., Gazzaniga, P."Failure of apoptosis and activation on NFκB by celecoxib and aspirin in lung cancer cell lines". Oncology Reports 17, no. 4 (2007): 823-828. https://doi.org/10.3892/or.17.4.823
Copy and paste a formatted citation
x
Spandidos Publications style
Gradilone A, Silvestri I, Scarpa S, Morrone S, Gandini O, Pulcinelli FM, Gianni W, Frati L, Aglianò AM, Gazzaniga P, Gazzaniga P, et al: Failure of apoptosis and activation on NFκB by celecoxib and aspirin in lung cancer cell lines. Oncol Rep 17: 823-828, 2007.
APA
Gradilone, A., Silvestri, I., Scarpa, S., Morrone, S., Gandini, O., Pulcinelli, F.M. ... Gazzaniga, P. (2007). Failure of apoptosis and activation on NFκB by celecoxib and aspirin in lung cancer cell lines. Oncology Reports, 17, 823-828. https://doi.org/10.3892/or.17.4.823
MLA
Gradilone, A., Silvestri, I., Scarpa, S., Morrone, S., Gandini, O., Pulcinelli, F. M., Gianni, W., Frati, L., Aglianò, A. M., Gazzaniga, P."Failure of apoptosis and activation on NFκB by celecoxib and aspirin in lung cancer cell lines". Oncology Reports 17.4 (2007): 823-828.
Chicago
Gradilone, A., Silvestri, I., Scarpa, S., Morrone, S., Gandini, O., Pulcinelli, F. M., Gianni, W., Frati, L., Aglianò, A. M., Gazzaniga, P."Failure of apoptosis and activation on NFκB by celecoxib and aspirin in lung cancer cell lines". Oncology Reports 17, no. 4 (2007): 823-828. https://doi.org/10.3892/or.17.4.823
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