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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2007 Volume 17 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells

  • Authors:
    • Su-Bog Yee
    • Yeon Suk Song
    • Seung Hun Jeong
    • Hyung Sik Lee
    • Su Yeong Seo
    • Jae Hong Kim
    • Hongsuk Suh
    • Nam Deuk Kim
    • Young Hyun Yoo

  • View Affiliations / Copyright

    Affiliations: edical Science Research Center and College of Medicine (BK21 Program), Dong-A University, Busan 602-714, South Korea
  • Pages: 919-923
    |
    Published online on: April 1, 2007
       https://doi.org/10.3892/or.17.4.919
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Abstract

HS-1200, a synthetic chenodeoxycholic acid derivative, has cytotoxic activity in various human cancer cells. The present study was undertaken to examine whether HS-1200 sensitizes radiation-induced apoptosis in MCF-7 human breast carcinoma cells. Clonogenic assay elucidated that the combination treatment with HS-1200 and radiation induced more cytotoxic effects than the radiation treatment alone. Nuclear staining, DNA electrophoresis and Western blot analysis for poly(ADP-ribose) polymerase revealed that the increased cytotoxic effect by the combination treatment resulted from the augmentation of apoptosis. There was an increase in the expression level of Bax and its translocation onto the mitochondria, a reduction in the mitochondrial membrane potential in the earlier time-points, and the release of cytochrome c into the cytosol increased in the MCF-7 cells treated with radiation and HS-1200 compared to the cells treated only with radiation. Therefore, the synthetic bile acid derivative, HS-1200, could have the therapeutic potential as a radiosensitizer in MCF-7 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Yee S, Song YS, Jeong SH, Lee HS, Seo SY, Kim JH, Suh H, Kim ND and Yoo YH: A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells. Oncol Rep 17: 919-923, 2007.
APA
Yee, S., Song, Y.S., Jeong, S.H., Lee, H.S., Seo, S.Y., Kim, J.H. ... Yoo, Y.H. (2007). A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells. Oncology Reports, 17, 919-923. https://doi.org/10.3892/or.17.4.919
MLA
Yee, S., Song, Y. S., Jeong, S. H., Lee, H. S., Seo, S. Y., Kim, J. H., Suh, H., Kim, N. D., Yoo, Y. H."A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells". Oncology Reports 17.4 (2007): 919-923.
Chicago
Yee, S., Song, Y. S., Jeong, S. H., Lee, H. S., Seo, S. Y., Kim, J. H., Suh, H., Kim, N. D., Yoo, Y. H."A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells". Oncology Reports 17, no. 4 (2007): 919-923. https://doi.org/10.3892/or.17.4.919
Copy and paste a formatted citation
x
Spandidos Publications style
Yee S, Song YS, Jeong SH, Lee HS, Seo SY, Kim JH, Suh H, Kim ND and Yoo YH: A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells. Oncol Rep 17: 919-923, 2007.
APA
Yee, S., Song, Y.S., Jeong, S.H., Lee, H.S., Seo, S.Y., Kim, J.H. ... Yoo, Y.H. (2007). A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells. Oncology Reports, 17, 919-923. https://doi.org/10.3892/or.17.4.919
MLA
Yee, S., Song, Y. S., Jeong, S. H., Lee, H. S., Seo, S. Y., Kim, J. H., Suh, H., Kim, N. D., Yoo, Y. H."A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells". Oncology Reports 17.4 (2007): 919-923.
Chicago
Yee, S., Song, Y. S., Jeong, S. H., Lee, H. S., Seo, S. Y., Kim, J. H., Suh, H., Kim, N. D., Yoo, Y. H."A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells". Oncology Reports 17, no. 4 (2007): 919-923. https://doi.org/10.3892/or.17.4.919
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