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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2007 Volume 17 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2007 Volume 17 Issue 5

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Article

Expression of endothelial PDGF receptors α and β in breast cancer: Up-regulation of endothelial PDGF receptor β

  • Authors:
    • T. Vrekoussis
    • E. N. Stathopoulos
    • M. Kafousi
    • I. Navrozoglou
    • O. Zoras

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, University Hospital and Medical School, University of Ioannina, Ioannina, Greece
  • Pages: 1115-1119
    |
    Published online on: May 1, 2007
       https://doi.org/10.3892/or.17.5.1115
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Abstract

The PDGF pathway is essential in tumor angiogenesis. Although the expression of the PDGF receptors has been excessively studied on breast cancer cells, few studies exist on PDGFR expression on the tumor endothelial cells. In the present study, it is investigated whether endothelial PDGF receptors' expression is altered in breast cancer. Endothelial PDGFRα and β expression was initially studied under the influence of tumor conditioned medium derived from a breast cancer cell line. Following tissue culture experiments the endothelial expression of both receptors was studied on formalin-fixed paraffin-embedded tissue sections of normal breast and breast cancer specimens. The tissue culture experiment revealed a possible up-regulation of endothelial PDGFRβ by breast cancer environment. Immunohistochemistry verified the result since 69.7% of the breast cancer sections were positive for PDGFRβ compared to 43.3% of normal breast sections (p<0.05). No statistical difference was revealed by studying PDGFRα expression. In conclusion, our findings support the thesis of possible anti-PDGFRβ anti-angiogenic therapy, in cases of endothelial PDGFRβ-expressing breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Vrekoussis T, Stathopoulos EN, Kafousi M, Navrozoglou I and Zoras O: Expression of endothelial PDGF receptors α and β in breast cancer: Up-regulation of endothelial PDGF receptor β. Oncol Rep 17: 1115-1119, 2007.
APA
Vrekoussis, T., Stathopoulos, E.N., Kafousi, M., Navrozoglou, I., & Zoras, O. (2007). Expression of endothelial PDGF receptors α and β in breast cancer: Up-regulation of endothelial PDGF receptor β. Oncology Reports, 17, 1115-1119. https://doi.org/10.3892/or.17.5.1115
MLA
Vrekoussis, T., Stathopoulos, E. N., Kafousi, M., Navrozoglou, I., Zoras, O."Expression of endothelial PDGF receptors α and β in breast cancer: Up-regulation of endothelial PDGF receptor β". Oncology Reports 17.5 (2007): 1115-1119.
Chicago
Vrekoussis, T., Stathopoulos, E. N., Kafousi, M., Navrozoglou, I., Zoras, O."Expression of endothelial PDGF receptors α and β in breast cancer: Up-regulation of endothelial PDGF receptor β". Oncology Reports 17, no. 5 (2007): 1115-1119. https://doi.org/10.3892/or.17.5.1115
Copy and paste a formatted citation
x
Spandidos Publications style
Vrekoussis T, Stathopoulos EN, Kafousi M, Navrozoglou I and Zoras O: Expression of endothelial PDGF receptors α and β in breast cancer: Up-regulation of endothelial PDGF receptor β. Oncol Rep 17: 1115-1119, 2007.
APA
Vrekoussis, T., Stathopoulos, E.N., Kafousi, M., Navrozoglou, I., & Zoras, O. (2007). Expression of endothelial PDGF receptors α and β in breast cancer: Up-regulation of endothelial PDGF receptor β. Oncology Reports, 17, 1115-1119. https://doi.org/10.3892/or.17.5.1115
MLA
Vrekoussis, T., Stathopoulos, E. N., Kafousi, M., Navrozoglou, I., Zoras, O."Expression of endothelial PDGF receptors α and β in breast cancer: Up-regulation of endothelial PDGF receptor β". Oncology Reports 17.5 (2007): 1115-1119.
Chicago
Vrekoussis, T., Stathopoulos, E. N., Kafousi, M., Navrozoglou, I., Zoras, O."Expression of endothelial PDGF receptors α and β in breast cancer: Up-regulation of endothelial PDGF receptor β". Oncology Reports 17, no. 5 (2007): 1115-1119. https://doi.org/10.3892/or.17.5.1115
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