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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May 2007 Volume 17 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Pitavastatin inactivates NF-κB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells

  • Authors:
    • Juyong Wang
    • Isao Kitajima

  • View Affiliations / Copyright

    Affiliations: Department of Tumor, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China. wangjuyong1@126.com
  • Pages: 1149-1154
    |
    Published online on: May 1, 2007
       https://doi.org/10.3892/or.17.5.1149
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Abstract

The aim of the present study was to provide new mechanistic insight into the effect of pitavastatin at low dose on NF-κB activated by TNF-α in the human breast cancer cell line (MCF-7). We found that treatment of MCF-7 with 1 µM pitavastatin inhibited the proliferation and suppressed the nuclear expression of NF-κB p65 induced by TNF-α with Western blotting. Furthermore, EMSA showed that pitavastatin significantly reduced the DNA binding activity of NF-κB induced by TNF-α. Subsequently, luciferase assay revealed that pitavastatin (1 µM) inhibited the transcriptional activity of the NF-κB promoter, which was clearly related to the HMG-CoA reductase activity because addition of mevalonic acid (MEV) could elevate the NF-κB activity. Moreover, the Rho kinase inhibitor Y27632 abolished the effect of pitavastatin on NF-κB activity. Finally, the addition of TNF-α significantly increased IL-6 protein production, which was suppressed by the addition of pitavastatin. These results suggest that pitavastatin at low dose (1 µM) inhibits NF-κB activation and decreases IL-6 production induced by TNF-α. It is dependent on Rho kinase pathway in human breast cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Wang J and Kitajima I: Pitavastatin inactivates NF-κB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells. Oncol Rep 17: 1149-1154, 2007.
APA
Wang, J., & Kitajima, I. (2007). Pitavastatin inactivates NF-κB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells. Oncology Reports, 17, 1149-1154. https://doi.org/10.3892/or.17.5.1149
MLA
Wang, J., Kitajima, I."Pitavastatin inactivates NF-κB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells". Oncology Reports 17.5 (2007): 1149-1154.
Chicago
Wang, J., Kitajima, I."Pitavastatin inactivates NF-κB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells". Oncology Reports 17, no. 5 (2007): 1149-1154. https://doi.org/10.3892/or.17.5.1149
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J and Kitajima I: Pitavastatin inactivates NF-κB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells. Oncol Rep 17: 1149-1154, 2007.
APA
Wang, J., & Kitajima, I. (2007). Pitavastatin inactivates NF-κB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells. Oncology Reports, 17, 1149-1154. https://doi.org/10.3892/or.17.5.1149
MLA
Wang, J., Kitajima, I."Pitavastatin inactivates NF-κB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells". Oncology Reports 17.5 (2007): 1149-1154.
Chicago
Wang, J., Kitajima, I."Pitavastatin inactivates NF-κB and decreases IL-6 production through Rho kinase pathway in MCF-7 cells". Oncology Reports 17, no. 5 (2007): 1149-1154. https://doi.org/10.3892/or.17.5.1149
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