Oral Kaposi's sarcoma in Tanzania: Presentation, immunopathology and human herpesvirus-8 association

  • Authors:
    • Amos R. Mwakigonja
    • Fatemeh Pak
    • Pawan Pyakurel
    • Innocent J. Mosha
    • Willy K. Urassa
    • Ephata E. Kaaya
    • Peter Biberfeld
  • View Affiliations

  • Published online on: June 1, 2007     https://doi.org/10.3892/or.17.6.1291
  • Pages: 1291-1299
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Abstract

Oral Kaposi's sarcoma (OKS) from Tanzanian patients (78) at Muhimbili National Hospital/Muhimbili University College of Health Sciences corresponding to approximately 10% of KS registered during 1990-2005, were diagnosed (ELISA) as HIV-infected (OAKS) (74/78) and endemic KS (4/78). Females were 69.2% (54/78) with median age 31 and males 30.8% (24/78) with median age 38. More males (50%) had systemic KS than females (37%) and 4-times more multicentric OKS. All tested (34) oral KS patients sera had HHV-8 antibodies. Available (31/78) blood showed very low CD4+ T-lymphocyte counts. Most OKS (61.5%) had nodular histology. Immunostaining showed adult male nodular OAKS to have a significantly higher frequency of viral LANA+, endothelial CD34+ tumour spindle-cells (SC) and more Ki-67+ (median =24.1%) proliferating cells compared to females (17.2%). Juvenile nodular OAKS had more LANA+ and Ki-67+ cells than corresponding adult cases. Significantly more LANA+ and Ki-67+ cells were found in nodular OAKS compared to cutaneous HIV/AIDS Kaposi's sarcoma (CAKS). A positive correlation (60%) was found between the proliferation index (Ki-67+ cell frequency) and LANA+/CD34+ SC. OKS in Tanzania is since 1990, mostly seen in females, associated with HIV/AIDS and advanced (nodular) histopathology. Males have more systemic tumour burden while more females develop primary OAKS. HHV-8+ cells were more frequent in nodular male than female and in juvenile than adult nodular OAKS than cAKS. Higher tumoral HHV-8 content appeared to be correlated to proliferation index.

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June 2007
Volume 17 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Mwakigonja AR, Pak F, Pyakurel P, Mosha IJ, Urassa WK, Kaaya EE and Biberfeld P: Oral Kaposi's sarcoma in Tanzania: Presentation, immunopathology and human herpesvirus-8 association. Oncol Rep 17: 1291-1299, 2007
APA
Mwakigonja, A.R., Pak, F., Pyakurel, P., Mosha, I.J., Urassa, W.K., Kaaya, E.E., & Biberfeld, P. (2007). Oral Kaposi's sarcoma in Tanzania: Presentation, immunopathology and human herpesvirus-8 association. Oncology Reports, 17, 1291-1299. https://doi.org/10.3892/or.17.6.1291
MLA
Mwakigonja, A. R., Pak, F., Pyakurel, P., Mosha, I. J., Urassa, W. K., Kaaya, E. E., Biberfeld, P."Oral Kaposi's sarcoma in Tanzania: Presentation, immunopathology and human herpesvirus-8 association". Oncology Reports 17.6 (2007): 1291-1299.
Chicago
Mwakigonja, A. R., Pak, F., Pyakurel, P., Mosha, I. J., Urassa, W. K., Kaaya, E. E., Biberfeld, P."Oral Kaposi's sarcoma in Tanzania: Presentation, immunopathology and human herpesvirus-8 association". Oncology Reports 17, no. 6 (2007): 1291-1299. https://doi.org/10.3892/or.17.6.1291