Predictive value of vascular endothelial growth factor-C expression for local recurrence of rectal carcinoma

Noda,Eiji; Maeda,Kiyoshi; Inoue,Toru; Nishihara,Tamahiro; Nishiguchi,Yukio; Ohira,Masaichi; Hirakawa,Kosei

doi:10.3892/or.17.6.1327

June 2007 Volume 17 Issue 6

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June 2007 Volume 17 Issue 6

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Article

Predictive value of vascular endothelial growth factor-C expression for local recurrence of rectal carcinoma

Authors:
- Eiji Noda
- Kiyoshi Maeda
- Toru Inoue
- Tamahiro Nishihara
- Yukio Nishiguchi
- Masaichi Ohira
- Kosei Hirakawa
View Affiliations / Copyright

Affiliations: Department of Surgical Oncology, Osaka City University, Graduate School of Medicine, Osaka 545-8585, Japan. nodatch@med.osaka-cu.ac.jp
Pages: 1327-1331
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Published online on: June 1, 2007

https://doi.org/10.3892/or.17.6.1327
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Abstract

Vascular endothelial growth factor-C (VEGF-C) is considered to be a specific factor promoting lymphangiogenesis. There have been reports of a positive correlation between local recurrence of rectal carcinoma and lymphatic invasion by the tumor. The aim of this study was to determine the clinical significance of VEGF-C expression for identifying lymphangiogenesis as a predictor of the local recurrence of rectal carcinoma. One hundred surgical specimens of rectal carcinoma from patients with (n=26) or without (n=74) local recurrence were studied. VEGF-C protein expression was assessed immunohistochemically. The correlations between VEGF-C expression, various clinicopathologic factors, the microscopic lymphatic vessel density (MLVD), and lymphatic invasion were studied. The MLVD (determined by immunohistostaining for D2-40) was significantly higher in VEGF-C positive tumors than VEGF-C negative tumors. VEGF-C positivity was only correlated with lymphatic involvement. Moreover, multivariate analysis showed that VEGF-C protein expression was an independent risk factor for the local recurrence of rectal carcinoma, and patients with VEGF-C positive tumors had a significantly worse prognosis than those with VEGF-C negative tumors. Expression of VEGF-C may be a good predictor of the local recurrence of rectal carcinoma and may also be a useful prognostic indicator.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Predictive value of vascular endothelial growth factor-C expression for local recurrence of rectal carcinoma

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Abstract

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