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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2007 Volume 17 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes

  • Authors:
    • Xulong Zhang
    • Jian Zhang
    • Haiming Wei
    • Zhigang Tian

  • View Affiliations / Copyright

    Affiliations: Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, P.R. China
  • Pages: 1377-1382
    |
    Published online on: June 1, 2007
       https://doi.org/10.3892/or.17.6.1377
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Abstract

Double-stranded decoy oligodeoxynucleotide (ODN) is a promising approach for inhibiting gene transcription. Signal transducer and activator of transcription (STAT) 3, a potent transcription factor, is usually constitutively activated in a variety of malignancies, and considered as an attractive drug target. In this study, it was noted that STAT3 was overactivated in human lung cancer cells, and STAT3-decoy ODN, which was high-efficiently transfected into nucleus of cancer cells, significantly inhibited the proliferation of PG cells by inducing apoptosis or cell cycle arrest. The transcription levels of mcl-1, cyclin D1, bcl-xl and survivin were significantly decreased by 64.4, 56.1, 72.8% (P<0.01) and 31.8% (P<0.05), respectively; and the synthesis levels of bcl-xl and cyclin D1 in PG cells showed 64.5% (P<0.01) and 28.6% (P<0.05) decrease, respectively. Our study demonstrated that decoy-ODN targeting at activated STAT3 may potentially be used as an anti-lung cancer therapeutic approach.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Zhang J, Wei H and Tian Z: STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes. Oncol Rep 17: 1377-1382, 2007.
APA
Zhang, X., Zhang, J., Wei, H., & Tian, Z. (2007). STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes. Oncology Reports, 17, 1377-1382. https://doi.org/10.3892/or.17.6.1377
MLA
Zhang, X., Zhang, J., Wei, H., Tian, Z."STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes". Oncology Reports 17.6 (2007): 1377-1382.
Chicago
Zhang, X., Zhang, J., Wei, H., Tian, Z."STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes". Oncology Reports 17, no. 6 (2007): 1377-1382. https://doi.org/10.3892/or.17.6.1377
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Zhang J, Wei H and Tian Z: STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes. Oncol Rep 17: 1377-1382, 2007.
APA
Zhang, X., Zhang, J., Wei, H., & Tian, Z. (2007). STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes. Oncology Reports, 17, 1377-1382. https://doi.org/10.3892/or.17.6.1377
MLA
Zhang, X., Zhang, J., Wei, H., Tian, Z."STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes". Oncology Reports 17.6 (2007): 1377-1382.
Chicago
Zhang, X., Zhang, J., Wei, H., Tian, Z."STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes". Oncology Reports 17, no. 6 (2007): 1377-1382. https://doi.org/10.3892/or.17.6.1377
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