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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2007 Volume 17 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Enhancement of lymphokine-activated killer cell induction using anti-CD25 and anti-CTLA-4 monoclonal antibodies

  • Authors:
    • Riki Okita
    • Yoshiyuki Yamaguchi
    • Akiko Emi
    • Kazuo Matsuura
    • Tetsuya Toge

  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan
  • Pages: 1429-1435
    |
    Published online on: June 1, 2007
       https://doi.org/10.3892/or.17.6.1429
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Abstract

Immunosuppression may contribute to cancer progression, in which regulatory T (T-reg) cells have been demonstrated to play important roles. We investigated whether anti-CD25 (α-CD25) monoclonal antibody (mAb) and anti-cytotoxic T lymphocyte-associated antigen-4 (α-CTLA-4) mAb could augment in vitro proliferation and cytotoxic activity against cancer cell lines of lymphokine-activated killer (LAK) cells. Human LAK cells with immobilized α-CD3 Ab plus IL-2 were significantly augmented, including LAK/α-CD25 (10 µg ml, p=0.045) and LAK/α-CTLA-4 (5 µg/ml, p=0.025; 10 µg/ml, p=0.019). LAK/α-CD25 and LAK/α-CTLA-4 showed significant cytotoxic activities against gastric cancer cell lines (p<0.05). The phenotype of LAK cells showed that α-CD25 and α-CTLA-4 mAb more selectively induced the phenotype of CD8+ cells. The secretion of IFN-γ increased significantly in LAK/α-CTLA-4 (p=0.032). α-CD25 mAb reduced intracellular CTLA-4 (p=0.0069), and α-CTLA-4 mAb reduced intracellular FOXP3 (p=0.049), respectively. These results suggest that LAK cells are highly augmented in the presence of α-CD25 mAb and α-CTLA-4 mAb through the possible mechanism of the suppression of T-reg.

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Copy and paste a formatted citation
Spandidos Publications style
Okita R, Yamaguchi Y, Emi A, Matsuura K and Toge T: Enhancement of lymphokine-activated killer cell induction using anti-CD25 and anti-CTLA-4 monoclonal antibodies. Oncol Rep 17: 1429-1435, 2007.
APA
Okita, R., Yamaguchi, Y., Emi, A., Matsuura, K., & Toge, T. (2007). Enhancement of lymphokine-activated killer cell induction using anti-CD25 and anti-CTLA-4 monoclonal antibodies. Oncology Reports, 17, 1429-1435. https://doi.org/10.3892/or.17.6.1429
MLA
Okita, R., Yamaguchi, Y., Emi, A., Matsuura, K., Toge, T."Enhancement of lymphokine-activated killer cell induction using anti-CD25 and anti-CTLA-4 monoclonal antibodies". Oncology Reports 17.6 (2007): 1429-1435.
Chicago
Okita, R., Yamaguchi, Y., Emi, A., Matsuura, K., Toge, T."Enhancement of lymphokine-activated killer cell induction using anti-CD25 and anti-CTLA-4 monoclonal antibodies". Oncology Reports 17, no. 6 (2007): 1429-1435. https://doi.org/10.3892/or.17.6.1429
Copy and paste a formatted citation
x
Spandidos Publications style
Okita R, Yamaguchi Y, Emi A, Matsuura K and Toge T: Enhancement of lymphokine-activated killer cell induction using anti-CD25 and anti-CTLA-4 monoclonal antibodies. Oncol Rep 17: 1429-1435, 2007.
APA
Okita, R., Yamaguchi, Y., Emi, A., Matsuura, K., & Toge, T. (2007). Enhancement of lymphokine-activated killer cell induction using anti-CD25 and anti-CTLA-4 monoclonal antibodies. Oncology Reports, 17, 1429-1435. https://doi.org/10.3892/or.17.6.1429
MLA
Okita, R., Yamaguchi, Y., Emi, A., Matsuura, K., Toge, T."Enhancement of lymphokine-activated killer cell induction using anti-CD25 and anti-CTLA-4 monoclonal antibodies". Oncology Reports 17.6 (2007): 1429-1435.
Chicago
Okita, R., Yamaguchi, Y., Emi, A., Matsuura, K., Toge, T."Enhancement of lymphokine-activated killer cell induction using anti-CD25 and anti-CTLA-4 monoclonal antibodies". Oncology Reports 17, no. 6 (2007): 1429-1435. https://doi.org/10.3892/or.17.6.1429
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