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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2007 Volume 17 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2007 Volume 17 Issue 6

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Article

Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer

  • Authors:
    • Nahed El-Najjar
    • Najat Saliba
    • Salma Talhouk
    • Hala Gali-Muhtasib

  • View Affiliations / Copyright

    Affiliations: Department of Biology, American University of Beirut, Beirut, Lebanon
  • Pages: 1517-1523
    |
    Published online on: June 1, 2007
       https://doi.org/10.3892/or.17.6.1517
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Abstract

The potential chemopreventive properties of the crude extract of Onopordum cynarocephalum were evaluated. Growth inhibition was investigated in FHs74Int human normal intestinal cells and ModeK mouse normal intestinal cell line and in two human colon cancer cells HCT-116 (p53+/+) and HT-29 (p53+/−). The extract was not cytotoxic to FHs74Int cells at concentrations 2-fold higher than the IC50 of HCT-116 cells. The extract inhibited dose-dependently the growth of HCT-116 cells (IC50=0.18 mg/ml) to a greater extent than HT-29 cells (IC50=1.8 mg/ml). The p53 wild-type HCT-116 cells were more sensitive than p53 mutant HT-29 cells to the pro-apoptotic effects of the plant extract; five times lower concentrations were needed to induce apoptosis in HCT-116 cells. Apoptosis induction by the extract was associated with an increase in the expression of pro-apoptotic proteins such as p53 and Bax, and a significant inhibition of the anti-apoptotic protein Bcl-2. Significant decrease in cyclin D1 protein and increase in p21 protein was observed in extract-treated HCT-116 cells. In vivo, the crude extract injected intra-peritoneally reduced the number of tumors by 64% (p<0.0001) and decreased the mean size of aberrant crypt foci in the DMH model of colon cancer. These data collectively suggest that O. cynarocephalum has potential anti-colon cancer effects.

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Copy and paste a formatted citation
Spandidos Publications style
El-Najjar N, Saliba N, Talhouk S and Gali-Muhtasib H: Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer. Oncol Rep 17: 1517-1523, 2007.
APA
El-Najjar, N., Saliba, N., Talhouk, S., & Gali-Muhtasib, H. (2007). Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer. Oncology Reports, 17, 1517-1523. https://doi.org/10.3892/or.17.6.1517
MLA
El-Najjar, N., Saliba, N., Talhouk, S., Gali-Muhtasib, H."Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer". Oncology Reports 17.6 (2007): 1517-1523.
Chicago
El-Najjar, N., Saliba, N., Talhouk, S., Gali-Muhtasib, H."Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer". Oncology Reports 17, no. 6 (2007): 1517-1523. https://doi.org/10.3892/or.17.6.1517
Copy and paste a formatted citation
x
Spandidos Publications style
El-Najjar N, Saliba N, Talhouk S and Gali-Muhtasib H: Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer. Oncol Rep 17: 1517-1523, 2007.
APA
El-Najjar, N., Saliba, N., Talhouk, S., & Gali-Muhtasib, H. (2007). Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer. Oncology Reports, 17, 1517-1523. https://doi.org/10.3892/or.17.6.1517
MLA
El-Najjar, N., Saliba, N., Talhouk, S., Gali-Muhtasib, H."Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer". Oncology Reports 17.6 (2007): 1517-1523.
Chicago
El-Najjar, N., Saliba, N., Talhouk, S., Gali-Muhtasib, H."Onopordum cynarocephalum induces apoptosis and protects against 1,2 dimethylhydrazine-induced colon cancer". Oncology Reports 17, no. 6 (2007): 1517-1523. https://doi.org/10.3892/or.17.6.1517
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