Repeat reduction surgery after an initial hepatectomy for patients with colorectal cancer

  • Authors:
    • Kenji Matsuda
    • Tsukasa Hotta
    • Kazuhisa Uchiyama
    • Masaji Tani
    • Katsunari Takifuji
    • Shozo Yokoyama
    • Takashi Higashiguchi
    • Toshiji Tominaga
    • Yoshimasa Oku
    • Toru Nasu
    • Hiroki Yamaue
  • View Affiliations

  • Published online on: July 1, 2007     https://doi.org/10.3892/or.18.1.189
  • Pages: 189-194
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A hepatectomy is the only treatment offering long-term survival in patients with colorectal liver metastases. However, 70-80% of the patients with a complete resection develop recurrent disease after an initial hepatectomy. Sixty-one patients who underwent metastases from colorectal carcinoma with a curative hepatectomy were entered into this study. Recurrence after hepatectomy was observed in 41 patients (67.2%). We reviewed the outcome of these 41 patients. Repeat reduction surgery was performed on 16 out of 41 patients (39.0%). According to a multivariate analysis, repeat reduction surgery and tumor size were found to be independent prognostic factors for the survival rate (p=0.007, p=0.018). Furthermore, in the group that underwent repeat reduction surgery, the rate of positive lymph nodes was significantly lower in the primary lesions, and the disease-free interval (DFI) was also significantly longer than in the group that did not undergo repeat reduction surgery (p=0.023, p=0.045), respectively. Repeat reduction surgery was found to be the most important prognostic factor. Patients with a longer DFI and with negative lymph node findings at the primary site may therefore be considered to be good candidates for repeat reduction surgery.

Related Articles

Journal Cover

July 2007
Volume 18 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Matsuda K, Hotta T, Uchiyama K, Tani M, Takifuji K, Yokoyama S, Higashiguchi T, Tominaga T, Oku Y, Nasu T, Nasu T, et al: Repeat reduction surgery after an initial hepatectomy for patients with colorectal cancer. Oncol Rep 18: 189-194, 2007
APA
Matsuda, K., Hotta, T., Uchiyama, K., Tani, M., Takifuji, K., Yokoyama, S. ... Yamaue, H. (2007). Repeat reduction surgery after an initial hepatectomy for patients with colorectal cancer. Oncology Reports, 18, 189-194. https://doi.org/10.3892/or.18.1.189
MLA
Matsuda, K., Hotta, T., Uchiyama, K., Tani, M., Takifuji, K., Yokoyama, S., Higashiguchi, T., Tominaga, T., Oku, Y., Nasu, T., Yamaue, H."Repeat reduction surgery after an initial hepatectomy for patients with colorectal cancer". Oncology Reports 18.1 (2007): 189-194.
Chicago
Matsuda, K., Hotta, T., Uchiyama, K., Tani, M., Takifuji, K., Yokoyama, S., Higashiguchi, T., Tominaga, T., Oku, Y., Nasu, T., Yamaue, H."Repeat reduction surgery after an initial hepatectomy for patients with colorectal cancer". Oncology Reports 18, no. 1 (2007): 189-194. https://doi.org/10.3892/or.18.1.189