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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2007 Volume 18 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July 2007 Volume 18 Issue 1

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Article

VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro

  • Authors:
    • Xiaoyan Shi
    • Gang Chen
    • Hui Xing
    • Danhui Weng
    • Xiangyang Bai
    • Ding Ma

  • View Affiliations / Copyright

    Affiliations: Cancer Biology Research Center, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Hubei 430030, P.R. China
  • Pages: 241-247
    |
    Published online on: July 1, 2007
       https://doi.org/10.3892/or.18.1.241
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Abstract

The study was conducted to clarify the expression and biological significance of VEGF-C and VEGFR-3 in human cervical cancer cell lines and to investigate the correlation between VEGF-C and cyclooxygenase-2 (COX-2) expression in these cells. Flow cytometry, Western blotting, RT-PCR, cell immunochemistry assay, cell proliferation assay, in vitro invasion assay and cell immunochemistry assay were used to detect the gene expression and to evaluate the biological features in test cell lines. VEGF-C expression was low while VEGFR-3 was quiet high in all cell lines detected. COX-2 expression coincided with that of VEGF-C. Recombinant human VEFG-C-treated HeLa cells showed increased proliferation and invasion in a dose-depended manner while NS398, a specific inhibitor of COX-2, blocked the invasive ability of HeLa. VEGF-C and its VEGFR-3 played a crucial role in the regulation of tumor growth and metastasis in cervical cell lines, and COX-2 might be a regulator of VEGF-C expression.

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Copy and paste a formatted citation
Spandidos Publications style
Shi X, Chen G, Xing H, Weng D, Bai X and Ma D: VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro. Oncol Rep 18: 241-247, 2007.
APA
Shi, X., Chen, G., Xing, H., Weng, D., Bai, X., & Ma, D. (2007). VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro. Oncology Reports, 18, 241-247. https://doi.org/10.3892/or.18.1.241
MLA
Shi, X., Chen, G., Xing, H., Weng, D., Bai, X., Ma, D."VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro". Oncology Reports 18.1 (2007): 241-247.
Chicago
Shi, X., Chen, G., Xing, H., Weng, D., Bai, X., Ma, D."VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro". Oncology Reports 18, no. 1 (2007): 241-247. https://doi.org/10.3892/or.18.1.241
Copy and paste a formatted citation
x
Spandidos Publications style
Shi X, Chen G, Xing H, Weng D, Bai X and Ma D: VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro. Oncol Rep 18: 241-247, 2007.
APA
Shi, X., Chen, G., Xing, H., Weng, D., Bai, X., & Ma, D. (2007). VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro. Oncology Reports, 18, 241-247. https://doi.org/10.3892/or.18.1.241
MLA
Shi, X., Chen, G., Xing, H., Weng, D., Bai, X., Ma, D."VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro". Oncology Reports 18.1 (2007): 241-247.
Chicago
Shi, X., Chen, G., Xing, H., Weng, D., Bai, X., Ma, D."VEGF-C, VEGFR-3, and COX-2 enhances growth and metastasis of human cervical carcinoma cell lines in vitro". Oncology Reports 18, no. 1 (2007): 241-247. https://doi.org/10.3892/or.18.1.241
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