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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2007 Volume 18 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2007 Volume 18 Issue 1

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Article

Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium

  • Authors:
    • Magdalena Brys
    • Andrzej Semczuk
    • Tomasz Rechberger
    • Wanda M. Krajewska

  • View Affiliations / Copyright

    Affiliations: Department of Cytobiochemistry, University of Lodz, Lodz 90-237, Poland. zreg@biol.uni.lodz.pl
  • Pages: 261-265
    |
    Published online on: July 1, 2007
       https://doi.org/10.3892/or.18.1.261
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Abstract

Overexpression of the erbB-1 (EGFR, epidermal growth factor receptor) and erbB-2 (HER2/neu) proteins contributes to the aggressive behavior of malignant tumors originating from the endometrium. We currently examined whether the trend of these proteins to overexpression is a direct effect of their gene transcriptional activities. Expression of the erbB-1/erbB-2 genes was measured applying the quantitative RT-PCR technique in 25 uterine carcinomas, 12 normal endometria, a carcinosarcoma and a case of botryoid sarcoma of the uterine cervix. We showed that erbB-1 mRNA was overexpressed in 48% (12/25) and erbB-2 mRNA was overexpressed in 8% (2/25) of the analysed tumors. The level of expression appeared to be significantly higher in the malignant tumors as compared to the benign ones for erbB-1 and for erbB-2 (p=0.0001 and p=0.008, respectively). A significant correlation between erbB-1 overexpression and tumor differentiation was found (Spearman rank correlation test, p<0.001). Concomitant erbB-1 and erbB-2 overexpression was detected only in 1 out of 25 (4%) uterine neoplasms. erbB-1 was overexpressed in a sarcoma botryoides of the uterine cervix. Our data suggest that erbB-1/erbB-2 overexpression is a direct effect of higher than normal transcriptional activity of the encoding genes in a subset of human endometrial carcinomas.

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Copy and paste a formatted citation
Spandidos Publications style
Brys M, Semczuk A, Rechberger T and Krajewska WM: Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium. Oncol Rep 18: 261-265, 2007.
APA
Brys, M., Semczuk, A., Rechberger, T., & Krajewska, W.M. (2007). Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium. Oncology Reports, 18, 261-265. https://doi.org/10.3892/or.18.1.261
MLA
Brys, M., Semczuk, A., Rechberger, T., Krajewska, W. M."Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium". Oncology Reports 18.1 (2007): 261-265.
Chicago
Brys, M., Semczuk, A., Rechberger, T., Krajewska, W. M."Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium". Oncology Reports 18, no. 1 (2007): 261-265. https://doi.org/10.3892/or.18.1.261
Copy and paste a formatted citation
x
Spandidos Publications style
Brys M, Semczuk A, Rechberger T and Krajewska WM: Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium. Oncol Rep 18: 261-265, 2007.
APA
Brys, M., Semczuk, A., Rechberger, T., & Krajewska, W.M. (2007). Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium. Oncology Reports, 18, 261-265. https://doi.org/10.3892/or.18.1.261
MLA
Brys, M., Semczuk, A., Rechberger, T., Krajewska, W. M."Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium". Oncology Reports 18.1 (2007): 261-265.
Chicago
Brys, M., Semczuk, A., Rechberger, T., Krajewska, W. M."Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium". Oncology Reports 18, no. 1 (2007): 261-265. https://doi.org/10.3892/or.18.1.261
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