Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium

  • Authors:
    • Magdalena Brys
    • Andrzej Semczuk
    • Tomasz Rechberger
    • Wanda M. Krajewska
  • View Affiliations

  • Published online on: July 1, 2007     https://doi.org/10.3892/or.18.1.261
  • Pages: 261-265
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Overexpression of the erbB-1 (EGFR, epidermal growth factor receptor) and erbB-2 (HER2/neu) proteins contributes to the aggressive behavior of malignant tumors originating from the endometrium. We currently examined whether the trend of these proteins to overexpression is a direct effect of their gene transcriptional activities. Expression of the erbB-1/erbB-2 genes was measured applying the quantitative RT-PCR technique in 25 uterine carcinomas, 12 normal endometria, a carcinosarcoma and a case of botryoid sarcoma of the uterine cervix. We showed that erbB-1 mRNA was overexpressed in 48% (12/25) and erbB-2 mRNA was overexpressed in 8% (2/25) of the analysed tumors. The level of expression appeared to be significantly higher in the malignant tumors as compared to the benign ones for erbB-1 and for erbB-2 (p=0.0001 and p=0.008, respectively). A significant correlation between erbB-1 overexpression and tumor differentiation was found (Spearman rank correlation test, p<0.001). Concomitant erbB-1 and erbB-2 overexpression was detected only in 1 out of 25 (4%) uterine neoplasms. erbB-1 was overexpressed in a sarcoma botryoides of the uterine cervix. Our data suggest that erbB-1/erbB-2 overexpression is a direct effect of higher than normal transcriptional activity of the encoding genes in a subset of human endometrial carcinomas.

Related Articles

Journal Cover

July 2007
Volume 18 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Brys M, Semczuk A, Rechberger T and Krajewska WM: Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium. Oncol Rep 18: 261-265, 2007.
APA
Brys, M., Semczuk, A., Rechberger, T., & Krajewska, W.M. (2007). Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium. Oncology Reports, 18, 261-265. https://doi.org/10.3892/or.18.1.261
MLA
Brys, M., Semczuk, A., Rechberger, T., Krajewska, W. M."Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium". Oncology Reports 18.1 (2007): 261-265.
Chicago
Brys, M., Semczuk, A., Rechberger, T., Krajewska, W. M."Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium". Oncology Reports 18, no. 1 (2007): 261-265. https://doi.org/10.3892/or.18.1.261