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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2007 Volume 18 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Abrogation of the p16-retinoblastoma-cyclin D1 pathway in head and neck squamous cell carcinomas

  • Authors:
    • Hun-Woong Park
    • Si-Youn Song
    • Tae-Jin Lee
    • Daewon Jeong
    • Tae-Yoon Lee

  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, College of Medicine, Yeungnam University, Daegu 705-717, Korea
  • Pages: 267-272
    |
    Published online on: July 1, 2007
       https://doi.org/10.3892/or.18.1.267
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Abstract

In the present study, we analyzed p16, retinoblastoma (Rb), and cyclin D1 abnormalities in head and neck squamous cell carcinoma (HNSCC) tissues and cell lines from Korean patients. We found a 40% loss of heterozygosity at the D9S171 locus (9p21 region) these tissues. All eight of the HNSCC cell lines did not express the p16 protein, and in two of these cell lines (Amc-HN-6 and 8), this was due to a deletion of the p16 gene. Three of the cell lines (Amc-HN-3 to 5) that expressed the p16 mRNA had the same nonsense mutation at codon 50 (CGA-Arg to TGA-Ter). The Amc-HN-1 and Amc-HN-7 cell lines, which did not express the p16 mRNA, had a missense mutation at codon 9 (GCC-Ala to GTC-Val) and a silent mutation at codon 106 (CCC-Pro to CCA), respectively. The Amc-HN-2 cell line (p16 exon-positive/mRNA-negative) had a single base deletion at codon 38 (CGG-Arg to CG), which resulted in a frameshift and a consequent stop signal at codon 44. The Rb protein was detected in all of the eight cell lines, although it was inactive in five of these due to hyperphosphorylation. The inverse relationship between p16 and Rb was 62.5% (5/8). Cyclin D1 was overexpressed in all of the eight cell lines. Our results suggest that the abrogation of p16, the overexpression of cyclin D1, and the consequent inactivation of Rb could be important factors in the carcinogenesis of HNSCCs.

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Copy and paste a formatted citation
Spandidos Publications style
Park H, Song S, Lee T, Jeong D and Lee T: Abrogation of the p16-retinoblastoma-cyclin D1 pathway in head and neck squamous cell carcinomas. Oncol Rep 18: 267-272, 2007.
APA
Park, H., Song, S., Lee, T., Jeong, D., & Lee, T. (2007). Abrogation of the p16-retinoblastoma-cyclin D1 pathway in head and neck squamous cell carcinomas. Oncology Reports, 18, 267-272. https://doi.org/10.3892/or.18.1.267
MLA
Park, H., Song, S., Lee, T., Jeong, D., Lee, T."Abrogation of the p16-retinoblastoma-cyclin D1 pathway in head and neck squamous cell carcinomas". Oncology Reports 18.1 (2007): 267-272.
Chicago
Park, H., Song, S., Lee, T., Jeong, D., Lee, T."Abrogation of the p16-retinoblastoma-cyclin D1 pathway in head and neck squamous cell carcinomas". Oncology Reports 18, no. 1 (2007): 267-272. https://doi.org/10.3892/or.18.1.267
Copy and paste a formatted citation
x
Spandidos Publications style
Park H, Song S, Lee T, Jeong D and Lee T: Abrogation of the p16-retinoblastoma-cyclin D1 pathway in head and neck squamous cell carcinomas. Oncol Rep 18: 267-272, 2007.
APA
Park, H., Song, S., Lee, T., Jeong, D., & Lee, T. (2007). Abrogation of the p16-retinoblastoma-cyclin D1 pathway in head and neck squamous cell carcinomas. Oncology Reports, 18, 267-272. https://doi.org/10.3892/or.18.1.267
MLA
Park, H., Song, S., Lee, T., Jeong, D., Lee, T."Abrogation of the p16-retinoblastoma-cyclin D1 pathway in head and neck squamous cell carcinomas". Oncology Reports 18.1 (2007): 267-272.
Chicago
Park, H., Song, S., Lee, T., Jeong, D., Lee, T."Abrogation of the p16-retinoblastoma-cyclin D1 pathway in head and neck squamous cell carcinomas". Oncology Reports 18, no. 1 (2007): 267-272. https://doi.org/10.3892/or.18.1.267
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