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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2007 Volume 18 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2007 Volume 18 Issue 1

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Article

Expression of Epstein-Barr virus in renal cell carcinoma

  • Authors:
    • Misuzu Shimakage
    • Kunimitsu Kawahara
    • Shizuko Harada
    • Toshiyuki Sasagawa
    • Toshiaki Shinka
    • Toshitsugu Oka
  • View Affiliations / Copyright

    Affiliations: Clinical Reseach Institute, National Hospital Organization, Osaka National Hospital, Osaka 540-0006, Japan. misuzu_s@wakayama2.hosp.go.jp
  • Pages: 41-46
    |
    Published online on: July 1, 2007
       https://doi.org/10.3892/or.18.1.41
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Abstract

There have been few studies regarding the etiology of renal cell carcinoma. To examine the possible involvement of Epstein-Barr virus (EBV) in this disease, 9 renal cell carcinoma (RCC), 2 nephroblastoma (Wilms' tumor) and 2 RCC cell lines were subjected to mRNA in situ hybridization and indirect immunofluorescence staining. Messenger RNA in situ hybridization using BamHIW, EBNA LP, EBNA 2 and EBER1 probes of EBV revealed signals in all the examined samples, although some samples showed weak signals using the EBNA LP probe. Indirect immunofluorescence staining using anti-EBNA LP, anti-EBNA2, anti-LMP1 and anti-BZLF1 antibodies showed definitive fluorescence. PCR also revealed EBV DNA in all 8 RCC specimens including 7 cases other than hybridization and fluorescence. EBV infected all the RCC and nephroblastoma irrespective of the histological or clinical stage. On the other hand, EBV expression was stronger in papillary and clear cell-type RCC than chromophobe cell-type, as well as being stronger in the higher grades of RCC. These results suggest that the expression of EBV may be involved in the pathogenesis of RCC and nephroblastoma.

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Copy and paste a formatted citation
Spandidos Publications style
Shimakage M, Kawahara K, Harada S, Sasagawa T, Shinka T and Oka T: Expression of Epstein-Barr virus in renal cell carcinoma. Oncol Rep 18: 41-46, 2007.
APA
Shimakage, M., Kawahara, K., Harada, S., Sasagawa, T., Shinka, T., & Oka, T. (2007). Expression of Epstein-Barr virus in renal cell carcinoma. Oncology Reports, 18, 41-46. https://doi.org/10.3892/or.18.1.41
MLA
Shimakage, M., Kawahara, K., Harada, S., Sasagawa, T., Shinka, T., Oka, T."Expression of Epstein-Barr virus in renal cell carcinoma". Oncology Reports 18.1 (2007): 41-46.
Chicago
Shimakage, M., Kawahara, K., Harada, S., Sasagawa, T., Shinka, T., Oka, T."Expression of Epstein-Barr virus in renal cell carcinoma". Oncology Reports 18, no. 1 (2007): 41-46. https://doi.org/10.3892/or.18.1.41
Copy and paste a formatted citation
x
Spandidos Publications style
Shimakage M, Kawahara K, Harada S, Sasagawa T, Shinka T and Oka T: Expression of Epstein-Barr virus in renal cell carcinoma. Oncol Rep 18: 41-46, 2007.
APA
Shimakage, M., Kawahara, K., Harada, S., Sasagawa, T., Shinka, T., & Oka, T. (2007). Expression of Epstein-Barr virus in renal cell carcinoma. Oncology Reports, 18, 41-46. https://doi.org/10.3892/or.18.1.41
MLA
Shimakage, M., Kawahara, K., Harada, S., Sasagawa, T., Shinka, T., Oka, T."Expression of Epstein-Barr virus in renal cell carcinoma". Oncology Reports 18.1 (2007): 41-46.
Chicago
Shimakage, M., Kawahara, K., Harada, S., Sasagawa, T., Shinka, T., Oka, T."Expression of Epstein-Barr virus in renal cell carcinoma". Oncology Reports 18, no. 1 (2007): 41-46. https://doi.org/10.3892/or.18.1.41
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