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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July 2007 Volume 18 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2007 Volume 18 Issue 1

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Article

Anti-tumor effects of bevacizumab in combination with paclitaxel on head and neck squamous cell carcinoma

  • Authors:
    • Kyoko Fujita
    • Daisuke Sano
    • Machiko Kimura
    • Yukiko Yamashita
    • Mariko Kawakami
    • Yukari Ishiguro
    • Goshi Nishimura
    • Hideki Matsuda
    • Mamoru Tsukuda

  • View Affiliations / Copyright

    Affiliations: Department of Biology and Function in Head and Neck, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan. t056043b@yokohama-cu.ac.jp
  • Pages: 47-51
    |
    Published online on: July 1, 2007
       https://doi.org/10.3892/or.18.1.47
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Abstract

Human tumors are dependent on angiogenesis for growth, and the vascular endothelial growth factor (VEGF) is a major regulator of this process. Bevacizumab (Avastin®), a monoclonal antibody directed against VEGF, has shown promise in treating a variety of cancers. In this study, we first examined the anti-tumor effects of bevacizumab on head and neck squamous cell carcinoma (HNSCC). Then we examined the effects of bevacizumab combined with paclitaxel, a chemotherapeutic agent, in HNSCC. This is the first demonstration of the anti-tumor effects of bevacizumab on HNSCC. In vitro, bevacizumab did not show any antiproliferative effects against the HNSCC cell lines. However, in vivo, bevacizumab showed dramatic anti-tumor effects against HNSCC tumor xenografts in mice. In addition, treatment with a bevacizumab-paclitaxel combination resulted in a remarkable inhibition of the HNSCC tumor xenografts, compared to the effects of each agent separately. A decreased blood vessel density and an increased apoptotic index were seen in the shrunken tumors. These results suggest that bevacizumab in combination with paclitaxel could have useful clinical application in HNSCC.

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Copy and paste a formatted citation
Spandidos Publications style
Fujita K, Sano D, Kimura M, Yamashita Y, Kawakami M, Ishiguro Y, Nishimura G, Matsuda H and Tsukuda M: Anti-tumor effects of bevacizumab in combination with paclitaxel on head and neck squamous cell carcinoma. Oncol Rep 18: 47-51, 2007.
APA
Fujita, K., Sano, D., Kimura, M., Yamashita, Y., Kawakami, M., Ishiguro, Y. ... Tsukuda, M. (2007). Anti-tumor effects of bevacizumab in combination with paclitaxel on head and neck squamous cell carcinoma. Oncology Reports, 18, 47-51. https://doi.org/10.3892/or.18.1.47
MLA
Fujita, K., Sano, D., Kimura, M., Yamashita, Y., Kawakami, M., Ishiguro, Y., Nishimura, G., Matsuda, H., Tsukuda, M."Anti-tumor effects of bevacizumab in combination with paclitaxel on head and neck squamous cell carcinoma". Oncology Reports 18.1 (2007): 47-51.
Chicago
Fujita, K., Sano, D., Kimura, M., Yamashita, Y., Kawakami, M., Ishiguro, Y., Nishimura, G., Matsuda, H., Tsukuda, M."Anti-tumor effects of bevacizumab in combination with paclitaxel on head and neck squamous cell carcinoma". Oncology Reports 18, no. 1 (2007): 47-51. https://doi.org/10.3892/or.18.1.47
Copy and paste a formatted citation
x
Spandidos Publications style
Fujita K, Sano D, Kimura M, Yamashita Y, Kawakami M, Ishiguro Y, Nishimura G, Matsuda H and Tsukuda M: Anti-tumor effects of bevacizumab in combination with paclitaxel on head and neck squamous cell carcinoma. Oncol Rep 18: 47-51, 2007.
APA
Fujita, K., Sano, D., Kimura, M., Yamashita, Y., Kawakami, M., Ishiguro, Y. ... Tsukuda, M. (2007). Anti-tumor effects of bevacizumab in combination with paclitaxel on head and neck squamous cell carcinoma. Oncology Reports, 18, 47-51. https://doi.org/10.3892/or.18.1.47
MLA
Fujita, K., Sano, D., Kimura, M., Yamashita, Y., Kawakami, M., Ishiguro, Y., Nishimura, G., Matsuda, H., Tsukuda, M."Anti-tumor effects of bevacizumab in combination with paclitaxel on head and neck squamous cell carcinoma". Oncology Reports 18.1 (2007): 47-51.
Chicago
Fujita, K., Sano, D., Kimura, M., Yamashita, Y., Kawakami, M., Ishiguro, Y., Nishimura, G., Matsuda, H., Tsukuda, M."Anti-tumor effects of bevacizumab in combination with paclitaxel on head and neck squamous cell carcinoma". Oncology Reports 18, no. 1 (2007): 47-51. https://doi.org/10.3892/or.18.1.47
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