X-linked inhibitor of apoptosis (XIAP) and XIAP-associated factor-1 expressions and their relationship to apoptosis in human hepatocellular carcinoma and non-cancerous liver tissues

  • Authors:
    • Ryosuke Sakemi
    • Hirohisa Yano
    • Sachiko Ogasawara
    • Jun Akiba
    • Osamu Nakashima
    • Suguru Fukahori
    • Michio Sata
    • Masamichi Kojiro
  • View Affiliations

  • Published online on: July 1, 2007     https://doi.org/10.3892/or.18.1.65
  • Pages: 65-70
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The X-linked inhibitor of apoptosis (XIAP) belongs to the inhibitor of apoptosis (IAP) family, and the action of XIAP is inhibited by XIAP-associated factor-1 (XAF1). In the present study, XIAP and XAF1 protein expressions and their relationship to apoptosis were investigated in hepatocellular carcinoma (HCC). We examined immunohistochemical expressions of XIAP and XAF1, and the number of apoptotic HCC cells in surgically resected tissues of 24 HCCs, consisting of 7 well-, 10 moderately and 7 poorly differentiated HCCs. As a result, XIAP and XAF1 expressions were identified in the cytoplasm of non-neoplastic and neoplastic hepatocytes. In the 24 HCCs, XIAP expression was not different according to the histological grade of HCC. In contrast, XAF1 expression was significantly lower in poorly differentiated than that in well- or moderately differentiated HCCs (P=0.001), or XIAP expression in poorly differentiated HCC (P<0.001). Apoptotic HCC cell number was significantly lower in poorly differentiated than that in well- or moderately differentiated HCCs (P<0.01). A significant relationship was observed between XAF1 expression and apoptotic cell number in HCC tissues. In conclusion, the present findings suggest that significantly low XAF1 expression, but not XIAP expression, in poorly differentiated HCC may relate to resistance to apoptosis.

Related Articles

Journal Cover

July 2007
Volume 18 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Sakemi R, Yano H, Ogasawara S, Akiba J, Nakashima O, Fukahori S, Sata M and Kojiro M: X-linked inhibitor of apoptosis (XIAP) and XIAP-associated factor-1 expressions and their relationship to apoptosis in human hepatocellular carcinoma and non-cancerous liver tissues. Oncol Rep 18: 65-70, 2007
APA
Sakemi, R., Yano, H., Ogasawara, S., Akiba, J., Nakashima, O., Fukahori, S. ... Kojiro, M. (2007). X-linked inhibitor of apoptosis (XIAP) and XIAP-associated factor-1 expressions and their relationship to apoptosis in human hepatocellular carcinoma and non-cancerous liver tissues. Oncology Reports, 18, 65-70. https://doi.org/10.3892/or.18.1.65
MLA
Sakemi, R., Yano, H., Ogasawara, S., Akiba, J., Nakashima, O., Fukahori, S., Sata, M., Kojiro, M."X-linked inhibitor of apoptosis (XIAP) and XIAP-associated factor-1 expressions and their relationship to apoptosis in human hepatocellular carcinoma and non-cancerous liver tissues". Oncology Reports 18.1 (2007): 65-70.
Chicago
Sakemi, R., Yano, H., Ogasawara, S., Akiba, J., Nakashima, O., Fukahori, S., Sata, M., Kojiro, M."X-linked inhibitor of apoptosis (XIAP) and XIAP-associated factor-1 expressions and their relationship to apoptosis in human hepatocellular carcinoma and non-cancerous liver tissues". Oncology Reports 18, no. 1 (2007): 65-70. https://doi.org/10.3892/or.18.1.65