Expression of glucose transporters in epithelial ovarian carcinoma: Correlation with clinical characteristics and tumor angiogenesis

  • Authors:
    • Miho Tsukioka
    • Yoshinari Matsumoto
    • Maiko Noriyuki
    • Chika Yoshida
    • Hiroyuki Nobeyama
    • Hiroyuki Yoshida
    • Tomoyo Yasui
    • Toshiyuki Sumi
    • Ken-ichi Honda
    • Osamu Ishiko
  • View Affiliations

  • Published online on: August 1, 2007     https://doi.org/10.3892/or.18.2.361
  • Pages: 361-367
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Abstract

We immunohistochemically examined the expression of the glucose transporters (GLUT)1, GLUT3 and GLUT4, in 154 tumor samples of epithelial ovarian carcinoma. In addition, we investigated the correlations between the expression of GLUTs and the vascular endothelial growth factor (VEGF), and microvessel count and clinical parameters. The rates of expression of GLUT1, GLUT3 and GLUT4 were 98.7%, 92.8% and 84.4%, respectively. GLUT1 and GLUT4 were both strongly expressed in serous adenocarcinoma, but weakly expressed in clear cell adenocarcinoma. The expressions of GLUT1 and GLUT4 correlated with the clinical disease stage. The expressions of GLUT1, GLUT3 and GLUT4 correlated positively with VEGF expression. The expression status for GLUT1, GLUT3, GLUT4 and VEGF did not represent a prognostic factor. These findings suggest that characteristic differences in the patterns of glucose uptake can exist according to the histological type and that GLUT1, GLUT3 and GLUT4 could be related to tumor angiogenesis in epithelial ovarian carcinoma.

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August 2007
Volume 18 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Tsukioka M, Matsumoto Y, Noriyuki M, Yoshida C, Nobeyama H, Yoshida H, Yasui T, Sumi T, Honda K, Ishiko O, Ishiko O, et al: Expression of glucose transporters in epithelial ovarian carcinoma: Correlation with clinical characteristics and tumor angiogenesis. Oncol Rep 18: 361-367, 2007.
APA
Tsukioka, M., Matsumoto, Y., Noriyuki, M., Yoshida, C., Nobeyama, H., Yoshida, H. ... Ishiko, O. (2007). Expression of glucose transporters in epithelial ovarian carcinoma: Correlation with clinical characteristics and tumor angiogenesis. Oncology Reports, 18, 361-367. https://doi.org/10.3892/or.18.2.361
MLA
Tsukioka, M., Matsumoto, Y., Noriyuki, M., Yoshida, C., Nobeyama, H., Yoshida, H., Yasui, T., Sumi, T., Honda, K., Ishiko, O."Expression of glucose transporters in epithelial ovarian carcinoma: Correlation with clinical characteristics and tumor angiogenesis". Oncology Reports 18.2 (2007): 361-367.
Chicago
Tsukioka, M., Matsumoto, Y., Noriyuki, M., Yoshida, C., Nobeyama, H., Yoshida, H., Yasui, T., Sumi, T., Honda, K., Ishiko, O."Expression of glucose transporters in epithelial ovarian carcinoma: Correlation with clinical characteristics and tumor angiogenesis". Oncology Reports 18, no. 2 (2007): 361-367. https://doi.org/10.3892/or.18.2.361