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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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August 2007 Volume 18 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2007 Volume 18 Issue 2

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Article

Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor γ, in colorectal adenocarcinoma

  • Authors:
    • Delphine Bouancheau
    • Anne Jarry
    • Stephanie Mottier
    • Claire Toquet
    • Damien Masson
    • Jean-François Mosnier
    • Christian L. Laboisse
    • Marc G. Denis

  • View Affiliations / Copyright

    Affiliations: INSERM U539, IFR26, Faculté de Médecine, F-44035 Nantes, France
  • Pages: 489-495
    |
    Published online on: August 1, 2007
       https://doi.org/10.3892/or.18.2.489
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Abstract

Peroxisome proliferator-activated receptor γ (PPARγ) agonists have been demonstrated to exert an inhibitory effect on cell growth, and to induce the cell differentiation and apoptosis of colorectal cancer cells. PPARγ was therefore proposed as a therapeutic target. Recently, a variant of PPARγ which functions as a dominant negative (ORF4) was described. Expression of this protein may prevent PPARγ ligand efficiency in colon cancer treatment. In an effort to evaluate the importance of this variant, we determined the expression level of PPARγ and that of the splicing variant ORF4 in a series of 28 human colon adenocarcinomas relative to paired normal mucosa by real-time PCR. PPARγ expression was found to be heterogeneous among tumors. ORF4 was also expressed, but represented <10% of the PPARγ transcripts. This low level was also found in several human colon cancer cell lines treated or not with a specific PPARγ ligand in preparations of isolated human colonic epithelial cells and in mouse colon. We conclude that ORF4 expression is a general phenomenon, and that its low level should not affect the efficiency of selective PPARγ modulators in colon cancer treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Bouancheau D, Jarry A, Mottier S, Toquet C, Masson D, Mosnier J, Laboisse CL and Denis MG: Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor γ, in colorectal adenocarcinoma. Oncol Rep 18: 489-495, 2007.
APA
Bouancheau, D., Jarry, A., Mottier, S., Toquet, C., Masson, D., Mosnier, J. ... Denis, M.G. (2007). Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor γ, in colorectal adenocarcinoma. Oncology Reports, 18, 489-495. https://doi.org/10.3892/or.18.2.489
MLA
Bouancheau, D., Jarry, A., Mottier, S., Toquet, C., Masson, D., Mosnier, J., Laboisse, C. L., Denis, M. G."Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor γ, in colorectal adenocarcinoma". Oncology Reports 18.2 (2007): 489-495.
Chicago
Bouancheau, D., Jarry, A., Mottier, S., Toquet, C., Masson, D., Mosnier, J., Laboisse, C. L., Denis, M. G."Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor γ, in colorectal adenocarcinoma". Oncology Reports 18, no. 2 (2007): 489-495. https://doi.org/10.3892/or.18.2.489
Copy and paste a formatted citation
x
Spandidos Publications style
Bouancheau D, Jarry A, Mottier S, Toquet C, Masson D, Mosnier J, Laboisse CL and Denis MG: Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor γ, in colorectal adenocarcinoma. Oncol Rep 18: 489-495, 2007.
APA
Bouancheau, D., Jarry, A., Mottier, S., Toquet, C., Masson, D., Mosnier, J. ... Denis, M.G. (2007). Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor γ, in colorectal adenocarcinoma. Oncology Reports, 18, 489-495. https://doi.org/10.3892/or.18.2.489
MLA
Bouancheau, D., Jarry, A., Mottier, S., Toquet, C., Masson, D., Mosnier, J., Laboisse, C. L., Denis, M. G."Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor γ, in colorectal adenocarcinoma". Oncology Reports 18.2 (2007): 489-495.
Chicago
Bouancheau, D., Jarry, A., Mottier, S., Toquet, C., Masson, D., Mosnier, J., Laboisse, C. L., Denis, M. G."Low expression of ORF4, a dominant negative variant of peroxisome proliferator-activated receptor γ, in colorectal adenocarcinoma". Oncology Reports 18, no. 2 (2007): 489-495. https://doi.org/10.3892/or.18.2.489
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