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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2007 Volume 18 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2007 Volume 18 Issue 3

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Article

Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells

  • Authors:
    • Bin Ling
    • Ying Zhou
    • Dingqing Feng
    • Guodong Shen
    • Ting Gao
    • Yongyun Shi
    • Haiming Wei
    • Zhigang Tian

  • View Affiliations / Copyright

    Affiliations: Anhui Provincial Hospital Affiliated to Anhui Medical University, 230001 Anhui, P.R. China. lingbin.ling@gmail.com
  • Pages: 659-664
    |
    Published online on: September 1, 2007
       https://doi.org/10.3892/or.18.3.659
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Abstract

Embryonic development associated gene (EDAG), which is overexpressed in hematopoietic neoplasms and leukemia cell lines, has been reported to participate in the leukemia cell differentiation and proliferation. This study investigated whether retrovirus-mediated transfer of a siRNA against EDAG can reduce the growth of leukemia cells which highly express EDAG in vitro and in vivo. The stable transfected cells were identified with RT-PCR, the effect of EDAG/siRNA on the growth of the human erythroleukemia cell line HEL was analyzed by MTT assay, and angiogenic factor IL-8 release was evaluated by ELISA and RT-PCR. The results showed that EDAG/siRNA can silence the expression of EDAG in HEL cells. Down-regulation of EDAG expression by retrovirus-mediated siRNA inhibited the cell proliferation and tumor growth. Knockdown of EDAG expression by siRNA is also associated with decreased expression of the anti-angiogenic factor IL-8, suggesting that EDAG stimulates tumor growth at least in part by regulating angiogenesis. This study suggests that siRNA-mediated gene silencing of EDAG could potentially be a therapeutic strategy for EDAG over-expressing leukemia cells.

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Copy and paste a formatted citation
Spandidos Publications style
Ling B, Zhou Y, Feng D, Shen G, Gao T, Shi Y, Wei H and Tian Z: Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells. Oncol Rep 18: 659-664, 2007.
APA
Ling, B., Zhou, Y., Feng, D., Shen, G., Gao, T., Shi, Y. ... Tian, Z. (2007). Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells. Oncology Reports, 18, 659-664. https://doi.org/10.3892/or.18.3.659
MLA
Ling, B., Zhou, Y., Feng, D., Shen, G., Gao, T., Shi, Y., Wei, H., Tian, Z."Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells". Oncology Reports 18.3 (2007): 659-664.
Chicago
Ling, B., Zhou, Y., Feng, D., Shen, G., Gao, T., Shi, Y., Wei, H., Tian, Z."Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells". Oncology Reports 18, no. 3 (2007): 659-664. https://doi.org/10.3892/or.18.3.659
Copy and paste a formatted citation
x
Spandidos Publications style
Ling B, Zhou Y, Feng D, Shen G, Gao T, Shi Y, Wei H and Tian Z: Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells. Oncol Rep 18: 659-664, 2007.
APA
Ling, B., Zhou, Y., Feng, D., Shen, G., Gao, T., Shi, Y. ... Tian, Z. (2007). Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells. Oncology Reports, 18, 659-664. https://doi.org/10.3892/or.18.3.659
MLA
Ling, B., Zhou, Y., Feng, D., Shen, G., Gao, T., Shi, Y., Wei, H., Tian, Z."Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells". Oncology Reports 18.3 (2007): 659-664.
Chicago
Ling, B., Zhou, Y., Feng, D., Shen, G., Gao, T., Shi, Y., Wei, H., Tian, Z."Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells". Oncology Reports 18, no. 3 (2007): 659-664. https://doi.org/10.3892/or.18.3.659
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