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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2007 Volume 18 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2007 Volume 18 Issue 3

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Article

Casein kinase II inhibition induces apoptosis in pancreatic cancer cells

  • Authors:
    • Rainer Hamacher
    • Dieter Saur
    • Ralph Fritsch
    • Maximilian Reichert
    • Roland M. Schmid
    • Günter Schneider

  • View Affiliations / Copyright

    Affiliations: Second Department of Internal Medicine, Technical University of Munich, D-81675 Munich, Germany
  • Pages: 695-701
    |
    Published online on: September 1, 2007
       https://doi.org/10.3892/or.18.3.695
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Abstract

Pancreatic cancer is one of the most common causes of cancer death in western civilization. The five-year survival rate is below 1% and of the 10% of patients with resectable disease only around one-fifth survives 5 years. Survival rates have not changed much during the last 20 years, demonstrating the inefficacy of current available therapies. To improve the prognosis of pancreatic cancer, there is the need to develop effective non-surgical treatment for this disease. The protein kinase casein kinase II (CK2) is a ubiquitously expressed serine-threonine kinase and its activity is enhanced in all human tumors examined so far. The contribution of CK2 to the tumor maintenance of pancreatic cancer has not been investigated. To investigate the function of CK2 in pancreatic cancer cells we used the CK2 specific inhibitors 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole and Apigenin. Furthermore, we interfered with CK2 expression using CK2 specific siRNAs. Interfering with CK2 function led to a reduction of pancreatic cancer cell viability, which was due to caspase-dependent apoptosis. The induction of apoptosis correlated with a reduced NF-κB-dependent transcriptional activity. This study validates CK2 as a molecular drug target in a preclinical in vitro model of pancreatic cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Hamacher R, Saur D, Fritsch R, Reichert M, Schmid RM and Schneider G: Casein kinase II inhibition induces apoptosis in pancreatic cancer cells. Oncol Rep 18: 695-701, 2007.
APA
Hamacher, R., Saur, D., Fritsch, R., Reichert, M., Schmid, R.M., & Schneider, G. (2007). Casein kinase II inhibition induces apoptosis in pancreatic cancer cells. Oncology Reports, 18, 695-701. https://doi.org/10.3892/or.18.3.695
MLA
Hamacher, R., Saur, D., Fritsch, R., Reichert, M., Schmid, R. M., Schneider, G."Casein kinase II inhibition induces apoptosis in pancreatic cancer cells". Oncology Reports 18.3 (2007): 695-701.
Chicago
Hamacher, R., Saur, D., Fritsch, R., Reichert, M., Schmid, R. M., Schneider, G."Casein kinase II inhibition induces apoptosis in pancreatic cancer cells". Oncology Reports 18, no. 3 (2007): 695-701. https://doi.org/10.3892/or.18.3.695
Copy and paste a formatted citation
x
Spandidos Publications style
Hamacher R, Saur D, Fritsch R, Reichert M, Schmid RM and Schneider G: Casein kinase II inhibition induces apoptosis in pancreatic cancer cells. Oncol Rep 18: 695-701, 2007.
APA
Hamacher, R., Saur, D., Fritsch, R., Reichert, M., Schmid, R.M., & Schneider, G. (2007). Casein kinase II inhibition induces apoptosis in pancreatic cancer cells. Oncology Reports, 18, 695-701. https://doi.org/10.3892/or.18.3.695
MLA
Hamacher, R., Saur, D., Fritsch, R., Reichert, M., Schmid, R. M., Schneider, G."Casein kinase II inhibition induces apoptosis in pancreatic cancer cells". Oncology Reports 18.3 (2007): 695-701.
Chicago
Hamacher, R., Saur, D., Fritsch, R., Reichert, M., Schmid, R. M., Schneider, G."Casein kinase II inhibition induces apoptosis in pancreatic cancer cells". Oncology Reports 18, no. 3 (2007): 695-701. https://doi.org/10.3892/or.18.3.695
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