Detection of drug-resistance genes using single bronchoscopy biopsy specimens

  • Authors:
    • Aurelie Trussardi-Regnier
    • Jean-Marc Millot
    • Marie-Claude Gorisse
    • Chantal Delvincourt
    • Alain Prevost
  • View Affiliations

  • Published online on: September 1, 2007     https://doi.org/10.3892/or.18.3.703
  • Pages: 703-708
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Abstract

Expression of three major resistance genes MDR1, MRP1 and LRP was investigated in small cell lung cancer, non-small cell lung cancer and metastasis. Single biopsies of bronchoscopy from 73 patients were performed to investigate expression of these three resistance genes by reverse transcriptase-polymerase chain reaction. Relations between gene expression and patient age, smoking status, histology, and chemotherapy were evaluated. A more frequent expression of MDR1 (77 versus 66%), MRP1 (91 versus 72%) and LRP (77 versus 63%) genes was detected in the malignant biopsies than in the non-malignant, respectively. In the metastasis biopsies, expression of these genes was markedly increased. No significant difference was observed between specimens before and after chemotherapy. Biopsies from progressing cancer showed higher MDR1, MRP1 and LRP gene expression. In conclusion, these data reveal a major role of MRP1 in intrinsic resistance and the high gene expression of MDR1 and MRP1 in relapsed diseases.

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September 2007
Volume 18 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Trussardi-Regnier A, Millot J, Gorisse M, Delvincourt C and Prevost A: Detection of drug-resistance genes using single bronchoscopy biopsy specimens. Oncol Rep 18: 703-708, 2007.
APA
Trussardi-Regnier, A., Millot, J., Gorisse, M., Delvincourt, C., & Prevost, A. (2007). Detection of drug-resistance genes using single bronchoscopy biopsy specimens. Oncology Reports, 18, 703-708. https://doi.org/10.3892/or.18.3.703
MLA
Trussardi-Regnier, A., Millot, J., Gorisse, M., Delvincourt, C., Prevost, A."Detection of drug-resistance genes using single bronchoscopy biopsy specimens". Oncology Reports 18.3 (2007): 703-708.
Chicago
Trussardi-Regnier, A., Millot, J., Gorisse, M., Delvincourt, C., Prevost, A."Detection of drug-resistance genes using single bronchoscopy biopsy specimens". Oncology Reports 18, no. 3 (2007): 703-708. https://doi.org/10.3892/or.18.3.703