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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September 2007 Volume 18 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2007 Volume 18 Issue 3

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Article

Adenoviral B7-H3 therapy induces tumor specific immune responses and reduces secondary metastasis in a murine model of colon cancer

  • Authors:
    • Catalin M. Lupu
    • Christoph Eisenbach
    • Alaviana D. Lupu
    • Michael A. Kuefner
    • Birgit Hoyler
    • Wolfgang Stremmel
    • Jens Encke

  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, University of Heidelberg, D-69120 Heidelberg, Germany
  • Pages: 745-748
    |
    Published online on: September 1, 2007
       https://doi.org/10.3892/or.18.3.745
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Abstract

Current cancer gene therapies aim at the induction of systemic antitumor immune responses. Tumors may deliver antigens to T-cells, but may lack the costimulatory signals necessary for mounting an effective response. The purpose of this study was to evaluate the efficacy of an adenoviral delivery of the B7-H3 costimulatory molecule in mice to induce antitumor immune responses. Colon cancers were established by orthotopic injection of syngeneic colon cancer cells into the cecum on Balb/c mice. After two weeks, these mice were treated by intratumoral injection of an adenovirus expressing mouse B7-H3 (Ad-B7-H3-GFP) or a control virus (Ad-GFP). Ad-B7-H3-GFP treatment resulted in a reduction of tumor size compared to the controls. In addition, the occurrence of secondary metastasis was significantly reduced in B7-H3 treated mice compared to control animals (lymph node 7/10 vs. 10/10; liver 2/10 vs. 8/10, p≤0.05). Ad-B7-H3-GFP treated animals showed significantly higher frequencies of tumor-specific interferon-γ producing CD8+ T-cells (p≤0.05) and higher interleukin-12 levels (p≤0.01) than control animals. This study demonstrates that adenoviral B7-H3 transfer is able to induce a specific cellular antitumor immune response leading to primary tumor regression and reduction of secondary metastasis in vivo.

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Copy and paste a formatted citation
Spandidos Publications style
Lupu CM, Eisenbach C, Lupu AD, Kuefner MA, Hoyler B, Stremmel W and Encke J: Adenoviral B7-H3 therapy induces tumor specific immune responses and reduces secondary metastasis in a murine model of colon cancer. Oncol Rep 18: 745-748, 2007.
APA
Lupu, C.M., Eisenbach, C., Lupu, A.D., Kuefner, M.A., Hoyler, B., Stremmel, W., & Encke, J. (2007). Adenoviral B7-H3 therapy induces tumor specific immune responses and reduces secondary metastasis in a murine model of colon cancer. Oncology Reports, 18, 745-748. https://doi.org/10.3892/or.18.3.745
MLA
Lupu, C. M., Eisenbach, C., Lupu, A. D., Kuefner, M. A., Hoyler, B., Stremmel, W., Encke, J."Adenoviral B7-H3 therapy induces tumor specific immune responses and reduces secondary metastasis in a murine model of colon cancer". Oncology Reports 18.3 (2007): 745-748.
Chicago
Lupu, C. M., Eisenbach, C., Lupu, A. D., Kuefner, M. A., Hoyler, B., Stremmel, W., Encke, J."Adenoviral B7-H3 therapy induces tumor specific immune responses and reduces secondary metastasis in a murine model of colon cancer". Oncology Reports 18, no. 3 (2007): 745-748. https://doi.org/10.3892/or.18.3.745
Copy and paste a formatted citation
x
Spandidos Publications style
Lupu CM, Eisenbach C, Lupu AD, Kuefner MA, Hoyler B, Stremmel W and Encke J: Adenoviral B7-H3 therapy induces tumor specific immune responses and reduces secondary metastasis in a murine model of colon cancer. Oncol Rep 18: 745-748, 2007.
APA
Lupu, C.M., Eisenbach, C., Lupu, A.D., Kuefner, M.A., Hoyler, B., Stremmel, W., & Encke, J. (2007). Adenoviral B7-H3 therapy induces tumor specific immune responses and reduces secondary metastasis in a murine model of colon cancer. Oncology Reports, 18, 745-748. https://doi.org/10.3892/or.18.3.745
MLA
Lupu, C. M., Eisenbach, C., Lupu, A. D., Kuefner, M. A., Hoyler, B., Stremmel, W., Encke, J."Adenoviral B7-H3 therapy induces tumor specific immune responses and reduces secondary metastasis in a murine model of colon cancer". Oncology Reports 18.3 (2007): 745-748.
Chicago
Lupu, C. M., Eisenbach, C., Lupu, A. D., Kuefner, M. A., Hoyler, B., Stremmel, W., Encke, J."Adenoviral B7-H3 therapy induces tumor specific immune responses and reduces secondary metastasis in a murine model of colon cancer". Oncology Reports 18, no. 3 (2007): 745-748. https://doi.org/10.3892/or.18.3.745
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