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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2007 Volume 18 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Reduced expression of TANGO in colon and hepatocellular carcinomas

  • Authors:
    • Stephanie Arndt
    • Anja K. Bosserhoff

  • View Affiliations / Copyright

    Affiliations: Institute of Pathology, University of Regensburg, D-93053 Regensburg, Germany
  • Pages: 885-891
    |
    Published online on: October 1, 2007
       https://doi.org/10.3892/or.18.4.885
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Abstract

The TANGO gene was originally identified as a new family member of the MIA gene family. The gene codes for a 14-kDa protein of so far unknown function. Recently, we identified TANGO as a tumor suppressor in malignant melanoma. In this study we evaluated TANGO transcription in different colon and hepatocellular carcinoma cell lines and tissue samples, to analyze whether loss of TANGO expression is a more general process in tumor development. TANGO was down-regulated or lost in all hepatocellular and colon cell lines compared to primary human hepatocytes or normal colon epithelial cells, respectively, and in most of the tumor samples compared to non-tumorous tissue. These results were confirmed in situ by immunohistochemistry on paraffin-embedded sections of colon and hepatocellular tumors. Functional assays with exogenous TANGO treatment of colon and hepatoma cell lines revealed reduced motility and invasion capacity. Our studies present for the first time the down-regulation of TANGO in colon and hepatocellular carcinoma and provide the first indications for a tumor suppressor role of the TANGO gene in human colon and hepatocellular carcinoma. Thus, functional relevant loss of TANGO expression may contribute to general tumor development and progression, and may provide a new target for therapeutic strategies.

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Copy and paste a formatted citation
Spandidos Publications style
Arndt S and Bosserhoff AK: Reduced expression of TANGO in colon and hepatocellular carcinomas. Oncol Rep 18: 885-891, 2007.
APA
Arndt, S., & Bosserhoff, A.K. (2007). Reduced expression of TANGO in colon and hepatocellular carcinomas. Oncology Reports, 18, 885-891. https://doi.org/10.3892/or.18.4.885
MLA
Arndt, S., Bosserhoff, A. K."Reduced expression of TANGO in colon and hepatocellular carcinomas". Oncology Reports 18.4 (2007): 885-891.
Chicago
Arndt, S., Bosserhoff, A. K."Reduced expression of TANGO in colon and hepatocellular carcinomas". Oncology Reports 18, no. 4 (2007): 885-891. https://doi.org/10.3892/or.18.4.885
Copy and paste a formatted citation
x
Spandidos Publications style
Arndt S and Bosserhoff AK: Reduced expression of TANGO in colon and hepatocellular carcinomas. Oncol Rep 18: 885-891, 2007.
APA
Arndt, S., & Bosserhoff, A.K. (2007). Reduced expression of TANGO in colon and hepatocellular carcinomas. Oncology Reports, 18, 885-891. https://doi.org/10.3892/or.18.4.885
MLA
Arndt, S., Bosserhoff, A. K."Reduced expression of TANGO in colon and hepatocellular carcinomas". Oncology Reports 18.4 (2007): 885-891.
Chicago
Arndt, S., Bosserhoff, A. K."Reduced expression of TANGO in colon and hepatocellular carcinomas". Oncology Reports 18, no. 4 (2007): 885-891. https://doi.org/10.3892/or.18.4.885
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