Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma

  • Authors:
    • Yoichiro Mori
    • Hideyuki Ishiguro
    • Yoshiyuki Kuwabara
    • Masahiro Kimura
    • Akira Mitsui
    • Horoki Kurehara
    • Ryota Mori
    • Keisuke Tomoda
    • Ryo Ogawa
    • Takeyasu Katada
    • Koshiro Harata
    • Yoshitaka Fujii
  • View Affiliations

  • Published online on: October 1, 2007     https://doi.org/10.3892/or.18.4.981
  • Pages: 981-985
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

In this study, we examined the expression of esophageal cancer-related gene 4 (ECRG4) mRNA and evaluated its clinical significance in esophageal squamous cell carcinoma (ESCC). ECRG4 mRNA expression was quantified by real-time RT-PCR in 63 ESCC and corresponding normal esophageal mucosal samples. ECRG4 mRNA expression levels were significantly lower in ESCC tissues compared with corresponding normal esophageal mucosa (P<0.0001), in patients with locally invasive T2-4 tumors compared with less invasive T1 tumors (P=0.0229) and in stage 4 tumors compared with stage 0-3 tumors (P=0.0120). Furthermore, low ECRG4 mRNA expression levels were associated with significantly shorter survival after surgery compared with high ECRG4 mRNA expression levels (P=0.0150) in ESCC patients. On the basis of multivariate analysis, we conclude that ECRG4 mRNA expression level could be a candidate for an independent prognostic factor for ESCC patients.

Related Articles

Journal Cover

October 2007
Volume 18 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Mori Y, Ishiguro H, Kuwabara Y, Kimura M, Mitsui A, Kurehara H, Mori R, Tomoda K, Ogawa R, Katada T, Katada T, et al: Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma. Oncol Rep 18: 981-985, 2007
APA
Mori, Y., Ishiguro, H., Kuwabara, Y., Kimura, M., Mitsui, A., Kurehara, H. ... Fujii, Y. (2007). Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma. Oncology Reports, 18, 981-985. https://doi.org/10.3892/or.18.4.981
MLA
Mori, Y., Ishiguro, H., Kuwabara, Y., Kimura, M., Mitsui, A., Kurehara, H., Mori, R., Tomoda, K., Ogawa, R., Katada, T., Harata, K., Fujii, Y."Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma". Oncology Reports 18.4 (2007): 981-985.
Chicago
Mori, Y., Ishiguro, H., Kuwabara, Y., Kimura, M., Mitsui, A., Kurehara, H., Mori, R., Tomoda, K., Ogawa, R., Katada, T., Harata, K., Fujii, Y."Expression of ECRG4 is an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma". Oncology Reports 18, no. 4 (2007): 981-985. https://doi.org/10.3892/or.18.4.981