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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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October 2007 Volume 18 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes

  • Authors:
    • Ganka N. Atanasova
    • Antonia R. Isaeva
    • Nikolai Zhelev
    • Yves Poumay
    • Vanyo I. Mitev

  • View Affiliations / Copyright

    Affiliations: Departments of Chemistry and Biochemistry, Medical University of Sofia, 1431 Sofia, Bulgaria
  • Pages: 999-1005
    |
    Published online on: October 1, 2007
       https://doi.org/10.3892/or.18.4.999
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Abstract

In the present study, we have investigated the effect of the chemical CDK-inhibitor CYC202 on E6 and E7-transformed keratinocytes, in which the function of the cellular cell cycle inhibitor p21Cip1 is abrogated by the viral genes. The cyto-toxicity and the inhibition of the cell growth were analysed by MTT assay and analysis of DNA synthesis respectively. The effect on some signalling molecules was tested by Western blot analysis. CYC202 effectively inhibited the proliferation of E6 and E7 keratinocytes in a dose-dependent manner. Treatment with CYC202 strongly increased the activity of p38 MAP kinase. Furthermore, it inhibited ERK1/2 at the highest concentration used and had no effect on the activity of JNK1/2. CYC202 also increased the phosphorylation of HSP27 and decreased the phosphorylation and DNA-binding activity of the transcriptional regulator c-Myc, in correlation with the corresponding upstream kinases p38 MAPK and ERK1/2. Our results provide additional data for the anti-proliferative actions and potency of the chemical CDK-inhibitor CYC202.

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Copy and paste a formatted citation
Spandidos Publications style
Atanasova GN, Isaeva AR, Zhelev N, Poumay Y and Mitev VI: Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes. Oncol Rep 18: 999-1005, 2007.
APA
Atanasova, G.N., Isaeva, A.R., Zhelev, N., Poumay, Y., & Mitev, V.I. (2007). Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes. Oncology Reports, 18, 999-1005. https://doi.org/10.3892/or.18.4.999
MLA
Atanasova, G. N., Isaeva, A. R., Zhelev, N., Poumay, Y., Mitev, V. I."Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes". Oncology Reports 18.4 (2007): 999-1005.
Chicago
Atanasova, G. N., Isaeva, A. R., Zhelev, N., Poumay, Y., Mitev, V. I."Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes". Oncology Reports 18, no. 4 (2007): 999-1005. https://doi.org/10.3892/or.18.4.999
Copy and paste a formatted citation
x
Spandidos Publications style
Atanasova GN, Isaeva AR, Zhelev N, Poumay Y and Mitev VI: Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes. Oncol Rep 18: 999-1005, 2007.
APA
Atanasova, G.N., Isaeva, A.R., Zhelev, N., Poumay, Y., & Mitev, V.I. (2007). Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes. Oncology Reports, 18, 999-1005. https://doi.org/10.3892/or.18.4.999
MLA
Atanasova, G. N., Isaeva, A. R., Zhelev, N., Poumay, Y., Mitev, V. I."Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes". Oncology Reports 18.4 (2007): 999-1005.
Chicago
Atanasova, G. N., Isaeva, A. R., Zhelev, N., Poumay, Y., Mitev, V. I."Effects of the CDK-inhibitor CYC202 on p38 MAPK, ERK1/2 and c-Myc activities in papillomavirus type 16 E6- and E7-transformed human keratinocytes". Oncology Reports 18, no. 4 (2007): 999-1005. https://doi.org/10.3892/or.18.4.999
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