Involvement of the serrated neoplasia pathway in inflammatory bowel disease-related colorectal oncogenesis

  • Authors:
    • Céline Bossard
    • Marc G. Denis
    • Stéphane Bézieau
    • Kalyane Bach-Ngohou
    • Arnaud Bourreille
    • Christian L. Laboisse
    • Jean-François Mosnier
  • View Affiliations

  • Published online on: November 1, 2007     https://doi.org/10.3892/or.18.5.1093
  • Pages: 1093-1097
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Abstract

The purpose of this study is to identify colorectal serrated lesions in the inflammatory mucosa of inflammatory bowel disease (IBD), to characterize their molecular status based on BRAF and KRAS mutations, mismatch-repair (MMR) deficiency and microsatellite instability (MSI), and to verify that these molecular alterations are specific to the ‘serrated neoplasia pathway’ in IBD. Neoplastic lesions from 36 patients with IBD were reviewed retrospectively, including 13 adenocarcinomas (1 mucinous and 12 conventional), 28 dysplasias [1 traditional serrated adenoma (TSA) and 27 conventional adenomas] and 1 hyperplastic polyp (HP). Both the HP and TSA exhibited the V600E BRAF mutation without MSI or MMR deficiency. The mucinous adenocarcinoma, close to the TSA, exhibited the BRAF mutation and MSI with loss of hMLH1. No KRAS mutations were found in these 3 lesions, and no BRAF mutations were found in the conventional ones. Serrated lesions exist in the inflammatory mucosa of IBD and are associated with a characteristic molecular profile, i.e. the appearance of the BRAF mutation as early as the hyperplastic polyp stage followed by MSI at the carcinoma stage. We therefore identified the serrated neoplasia pathway in IBD-related colorectal oncogenesis.

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November 2007
Volume 18 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Bossard C, Denis MG, Bézieau S, Bach-Ngohou K, Bourreille A, Laboisse CL and Mosnier J: Involvement of the serrated neoplasia pathway in inflammatory bowel disease-related colorectal oncogenesis. Oncol Rep 18: 1093-1097, 2007
APA
Bossard, C., Denis, M.G., Bézieau, S., Bach-Ngohou, K., Bourreille, A., Laboisse, C.L., & Mosnier, J. (2007). Involvement of the serrated neoplasia pathway in inflammatory bowel disease-related colorectal oncogenesis. Oncology Reports, 18, 1093-1097. https://doi.org/10.3892/or.18.5.1093
MLA
Bossard, C., Denis, M. G., Bézieau, S., Bach-Ngohou, K., Bourreille, A., Laboisse, C. L., Mosnier, J."Involvement of the serrated neoplasia pathway in inflammatory bowel disease-related colorectal oncogenesis". Oncology Reports 18.5 (2007): 1093-1097.
Chicago
Bossard, C., Denis, M. G., Bézieau, S., Bach-Ngohou, K., Bourreille, A., Laboisse, C. L., Mosnier, J."Involvement of the serrated neoplasia pathway in inflammatory bowel disease-related colorectal oncogenesis". Oncology Reports 18, no. 5 (2007): 1093-1097. https://doi.org/10.3892/or.18.5.1093