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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2007 Volume 18 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Immunohistochemical expression of VEGF-A and its ligands in non-neoplastic lesions of the breast sampling-assisted by dynamic angiothermography

  • Authors:
    • Adhemar Longatto Filho
    • Sandra M. Costa
    • Fernanda Milanezi
    • Daniele Montruccoli
    • Gian Carlo Montruccoli
    • Fatima Baltazar
    • Fernando C. Schmitt

  • View Affiliations / Copyright

    Affiliations: Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Campus of Gualtar, Braga, Portugal
  • Pages: 1201-1206
    |
    Published online on: November 1, 2007
       https://doi.org/10.3892/or.18.5.1201
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Abstract

The aim of this study was to investigate the expression of angiogenic markers, vascular endothelial growth factor A (VEGF-A) ligand and its receptors, VEGFR-1 and -2, in a series of biopsy-proven non-neoplastic lesions of the breast detected by dynamic angiothermography. We have also studied the vascular density demonstrated by CD31 immunoreactivity, in order to assess the potential of the imaging method to recognize lesions with an enhaced vascular network of clinical importance in routine breast examination. The lesions were classified as non-proliferative, proliferative without atypia and proliferative with atypia. VEGF was diffusely expressed in the epithelial cells of proliferative lesions in almost all cases. Similarly, VEGFR-1 and -2 also exhibited epithelial positive reactions in the majority of cases. VEGF-A and its receptors were also present in blood vessels. CD31 showed an increase in vascular proliferation at the periphery of proliferative epithelial lesions, but not in non-proliferative lesions. Our results, showing marked expression of VEGF by the epithelial proliferative lesions and neoangiogenesis at their periphery, confirm that these lesions can be detected by dynamic angiothermography.

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Copy and paste a formatted citation
Spandidos Publications style
Longatto Filho A, Costa SM, Milanezi F, Montruccoli D, Montruccoli GC, Baltazar F and Schmitt FC: Immunohistochemical expression of VEGF-A and its ligands in non-neoplastic lesions of the breast sampling-assisted by dynamic angiothermography. Oncol Rep 18: 1201-1206, 2007.
APA
Longatto Filho, A., Costa, S.M., Milanezi, F., Montruccoli, D., Montruccoli, G.C., Baltazar, F., & Schmitt, F.C. (2007). Immunohistochemical expression of VEGF-A and its ligands in non-neoplastic lesions of the breast sampling-assisted by dynamic angiothermography. Oncology Reports, 18, 1201-1206. https://doi.org/10.3892/or.18.5.1201
MLA
Longatto Filho, A., Costa, S. M., Milanezi, F., Montruccoli, D., Montruccoli, G. C., Baltazar, F., Schmitt, F. C."Immunohistochemical expression of VEGF-A and its ligands in non-neoplastic lesions of the breast sampling-assisted by dynamic angiothermography". Oncology Reports 18.5 (2007): 1201-1206.
Chicago
Longatto Filho, A., Costa, S. M., Milanezi, F., Montruccoli, D., Montruccoli, G. C., Baltazar, F., Schmitt, F. C."Immunohistochemical expression of VEGF-A and its ligands in non-neoplastic lesions of the breast sampling-assisted by dynamic angiothermography". Oncology Reports 18, no. 5 (2007): 1201-1206. https://doi.org/10.3892/or.18.5.1201
Copy and paste a formatted citation
x
Spandidos Publications style
Longatto Filho A, Costa SM, Milanezi F, Montruccoli D, Montruccoli GC, Baltazar F and Schmitt FC: Immunohistochemical expression of VEGF-A and its ligands in non-neoplastic lesions of the breast sampling-assisted by dynamic angiothermography. Oncol Rep 18: 1201-1206, 2007.
APA
Longatto Filho, A., Costa, S.M., Milanezi, F., Montruccoli, D., Montruccoli, G.C., Baltazar, F., & Schmitt, F.C. (2007). Immunohistochemical expression of VEGF-A and its ligands in non-neoplastic lesions of the breast sampling-assisted by dynamic angiothermography. Oncology Reports, 18, 1201-1206. https://doi.org/10.3892/or.18.5.1201
MLA
Longatto Filho, A., Costa, S. M., Milanezi, F., Montruccoli, D., Montruccoli, G. C., Baltazar, F., Schmitt, F. C."Immunohistochemical expression of VEGF-A and its ligands in non-neoplastic lesions of the breast sampling-assisted by dynamic angiothermography". Oncology Reports 18.5 (2007): 1201-1206.
Chicago
Longatto Filho, A., Costa, S. M., Milanezi, F., Montruccoli, D., Montruccoli, G. C., Baltazar, F., Schmitt, F. C."Immunohistochemical expression of VEGF-A and its ligands in non-neoplastic lesions of the breast sampling-assisted by dynamic angiothermography". Oncology Reports 18, no. 5 (2007): 1201-1206. https://doi.org/10.3892/or.18.5.1201
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