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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November 2007 Volume 18 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2007 Volume 18 Issue 5

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Article

Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells

  • Authors:
    • Jong-Wook Park
    • Kyung Jin Woo
    • Jung-Tae Lee
    • Jun Hee Lim
    • Tae-Jin Lee
    • Sang Hyun Kim
    • Yung Hyun Choi
    • Taeg Kyu Kwon
  • View Affiliations / Copyright

    Affiliations: Department of Immunology and Chronic Disease Research Center and Institute for Medical Science, School of Medicine, Keimyung University, Taegu 700-712, South Korea
  • Pages: 1269-1273
    |
    Published online on: November 1, 2007
       https://doi.org/10.3892/or.18.5.1269
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Abstract

Resveratrol (3,4',5 tri-hydroxystilbene), a naturally occurring polyphenolic compound highly enriched in grapes and red wine, has been shown to induce anti-proliferation and apoptosis of human cancer cell lines. Resveratrol-induced dose-dependent apoptotic cell death in colon carcinoma cells, was measured by FACS analysis. Treatment of HT29 human colon carcinoma cells with resveratrol was found to induce a number of signature ER stress markers; phosphorylation of eukaryotic initiation factor-2α (eIF-2α), ER stress-specific XBP1 splicing and CCAAT/enhancer-binding protein-homologous protein (CHOP). In addition, resveratrol induced up-regulation of glucose-regulated protein (GRP)-78, suggesting the induction of ER stress. Furthermore, the inhibition of caspase-4 activity by z-LEVD-fmk significantly reduced resveratrol-induced apoptosis. Taken together, the present study therefore provides strong evidence to support an important role of ER stress response in mediating the resveratrol-induced apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Park J, Woo KJ, Lee J, Lim JH, Lee T, Kim SH, Choi YH and Kwon TK: Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells. Oncol Rep 18: 1269-1273, 2007.
APA
Park, J., Woo, K.J., Lee, J., Lim, J.H., Lee, T., Kim, S.H. ... Kwon, T.K. (2007). Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells. Oncology Reports, 18, 1269-1273. https://doi.org/10.3892/or.18.5.1269
MLA
Park, J., Woo, K. J., Lee, J., Lim, J. H., Lee, T., Kim, S. H., Choi, Y. H., Kwon, T. K."Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells". Oncology Reports 18.5 (2007): 1269-1273.
Chicago
Park, J., Woo, K. J., Lee, J., Lim, J. H., Lee, T., Kim, S. H., Choi, Y. H., Kwon, T. K."Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells". Oncology Reports 18, no. 5 (2007): 1269-1273. https://doi.org/10.3892/or.18.5.1269
Copy and paste a formatted citation
x
Spandidos Publications style
Park J, Woo KJ, Lee J, Lim JH, Lee T, Kim SH, Choi YH and Kwon TK: Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells. Oncol Rep 18: 1269-1273, 2007.
APA
Park, J., Woo, K.J., Lee, J., Lim, J.H., Lee, T., Kim, S.H. ... Kwon, T.K. (2007). Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells. Oncology Reports, 18, 1269-1273. https://doi.org/10.3892/or.18.5.1269
MLA
Park, J., Woo, K. J., Lee, J., Lim, J. H., Lee, T., Kim, S. H., Choi, Y. H., Kwon, T. K."Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells". Oncology Reports 18.5 (2007): 1269-1273.
Chicago
Park, J., Woo, K. J., Lee, J., Lim, J. H., Lee, T., Kim, S. H., Choi, Y. H., Kwon, T. K."Resveratrol induces pro-apoptotic endoplasmic reticulum stress in human colon cancer cells". Oncology Reports 18, no. 5 (2007): 1269-1273. https://doi.org/10.3892/or.18.5.1269
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