Metastasis-associated protein 1 inhibits p53-induced apoptosis

  • Authors:
    • Hyo-Eun Moon
    • Hwanju Cheon
    • Myung-Shik Lee
  • View Affiliations

  • Published online on: November 1, 2007     https://doi.org/10.3892/or.18.5.1311
  • Pages: 1311-1314
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Abstract

Metastasis-associated protein 1 (MTA1) is highly upregulated in cancer cells with metastatic potential; however, the molecular mechanism by which MTA1 increases the metastatic potential of cancer cells is far from clear. We characterized the functional consequences of MTA1 overexpression on p53-induced apoptosis of cancer cells. MTA1 was associated with p53 in a co-immunoprecipitation assay. MTA1 also had deacetylation activity on p53 in human non-small cell lung cancer cells H1299 and human hepatoma cells SK-Hep1. MTA1 attenuated the transactivation and p21 induction by p53. Moreover, MTA1 expression decreased p53-mediated apoptosis. These results indicate that MTA1 inhibits p53-induced apoptosis by deacetylation of p53, which might be related to the increased metastatic potential of cancer cells with high MTA1 expression.

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November 2007
Volume 18 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Moon H, Cheon H and Lee M: Metastasis-associated protein 1 inhibits p53-induced apoptosis. Oncol Rep 18: 1311-1314, 2007
APA
Moon, H., Cheon, H., & Lee, M. (2007). Metastasis-associated protein 1 inhibits p53-induced apoptosis. Oncology Reports, 18, 1311-1314. https://doi.org/10.3892/or.18.5.1311
MLA
Moon, H., Cheon, H., Lee, M."Metastasis-associated protein 1 inhibits p53-induced apoptosis". Oncology Reports 18.5 (2007): 1311-1314.
Chicago
Moon, H., Cheon, H., Lee, M."Metastasis-associated protein 1 inhibits p53-induced apoptosis". Oncology Reports 18, no. 5 (2007): 1311-1314. https://doi.org/10.3892/or.18.5.1311