Anti-tumor activity of arginine deiminase via arginine deprivation in retinoblastoma

  • Authors:
    • Jeong Hun Kim
    • Jin Hyoung Kim
    • Young Suk Yu
    • Dong Hun Kim
    • Bon-Hong Min
    • Kyu-Won Kim
  • View Affiliations

  • Published online on: December 1, 2007     https://doi.org/10.3892/or.18.6.1373
  • Pages: 1373-1377
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Abstract

In spite of recent advances in the treatment of retinoblastoma, chemotherapy is still challenging in high-stage intraocular retinoblastoma or metastatic retinoblastoma. Here, we investigated whether arginine deprivation via arginine deiminase (ADI) could be a new anti-tumor therapy in retinoblastoma cells. Expression of argininosuccinate synthetase (ASS) was detected in human retinoblastoma tissues. Even with a high expression of ASS, ADI effectively inhibited the proliferation of retinoblastoma cells and induced retinoblastoma cell death in a dose-dependent manner. These results indicate that arginine deprivation via ADI could be another treatment option for retinoblastoma due to low ASS activity in retinoblastoma cells.

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December 2007
Volume 18 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Kim JH, Kim JH, Yu YS, Kim DH, Min B and Kim K: Anti-tumor activity of arginine deiminase via arginine deprivation in retinoblastoma. Oncol Rep 18: 1373-1377, 2007
APA
Kim, J.H., Kim, J.H., Yu, Y.S., Kim, D.H., Min, B., & Kim, K. (2007). Anti-tumor activity of arginine deiminase via arginine deprivation in retinoblastoma. Oncology Reports, 18, 1373-1377. https://doi.org/10.3892/or.18.6.1373
MLA
Kim, J. H., Kim, J. H., Yu, Y. S., Kim, D. H., Min, B., Kim, K."Anti-tumor activity of arginine deiminase via arginine deprivation in retinoblastoma". Oncology Reports 18.6 (2007): 1373-1377.
Chicago
Kim, J. H., Kim, J. H., Yu, Y. S., Kim, D. H., Min, B., Kim, K."Anti-tumor activity of arginine deiminase via arginine deprivation in retinoblastoma". Oncology Reports 18, no. 6 (2007): 1373-1377. https://doi.org/10.3892/or.18.6.1373