Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer

  • Authors:
    • M. Hidalgo-Pascual
    • J. J. Galan
    • M. Chaves-Conde
    • J. A. Ramírez-Armengol
    • C. Moreno
    • E. Calvo
    • P. Pelaez
    • C. Crespo
    • A. Ruiz
    • J. L. Royo
  • View Affiliations

  • Published online on: December 1, 2007     https://doi.org/10.3892/or.18.6.1583
  • Pages: 1583-1587
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Abstract

Colorectal cancer is one of the most prevalent cancers in developed countries. However, the genetic factors influencing its appearance remain far from being fully characterized. Recently, a G>A functional transition mapping the 3' untranslated region of the CXCL12 gene (rs1801157) has been found to be under-represented among rectal cancer patients when compared to colon cancer patients from a Swedish series. Here we present the results from an independent analysis of CXCL12 rs1801157 in a larger CRC series of Spanish origin in order to analyse the robustness of this association within a different European population. No significant difference was observed between controls and colon or rectal cancer patients. We were also unable to find a correlation between rs1801157 and different prognostic markers such as metastasis development or disease-free survival time. The epidemiologic data involving CXCL12 rs1801157 in colorectal cancer risk are discussed.

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December 2007
Volume 18 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hidalgo-Pascual M, Galan JJ, Chaves-Conde M, Ramírez-Armengol JA, Moreno C, Calvo E, Pelaez P, Crespo C, Ruiz A, Royo JL, Royo JL, et al: Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer. Oncol Rep 18: 1583-1587, 2007
APA
Hidalgo-Pascual, M., Galan, J.J., Chaves-Conde, M., Ramírez-Armengol, J.A., Moreno, C., Calvo, E. ... Royo, J.L. (2007). Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer. Oncology Reports, 18, 1583-1587. https://doi.org/10.3892/or.18.6.1583
MLA
Hidalgo-Pascual, M., Galan, J. J., Chaves-Conde, M., Ramírez-Armengol, J. A., Moreno, C., Calvo, E., Pelaez, P., Crespo, C., Ruiz, A., Royo, J. L."Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer". Oncology Reports 18.6 (2007): 1583-1587.
Chicago
Hidalgo-Pascual, M., Galan, J. J., Chaves-Conde, M., Ramírez-Armengol, J. A., Moreno, C., Calvo, E., Pelaez, P., Crespo, C., Ruiz, A., Royo, J. L."Analysis of CXCL12 3'UTR G>A polymorphism in colorectal cancer". Oncology Reports 18, no. 6 (2007): 1583-1587. https://doi.org/10.3892/or.18.6.1583