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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January 2008 Volume 19 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2008 Volume 19 Issue 1

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Article

CD1c+ and CD303+ dendritic cells in peripheral blood, lymph nodes and tumor tissue of patients with non-small cell lung cancer

  • Authors:
    • Jacek Tabarkiewicz
    • Pawel Rybojad
    • Andrzej Jablonka
    • Jacek Rolinski

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Immunology, Skubiszewski Medical University, 20-095 Lublin, Poland. tabar@mp.pl
  • Pages: 237-243
    |
    Published online on: January 1, 2008
       https://doi.org/10.3892/or.19.1.237
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Abstract

Dendritic cells (DCs) are the most potent antigen presenting cells, which can stimulate a cellular immune response against malignant tumor cells. Many authors have described the phenomenon of tumor infiltration by dendritic cells and emphasized an immunosuppressive tumor influence on DC function. In the present study, we examined the presence of myeloid CD1c+ (BDCA-1+) dendritic cells and lymphoid/plasmacytoid CD303+ (BDCA-2+) dendritic cells in peripheral blood, lymph nodes and cancer tissue of patients with non-small cell lung cancer (NSCLC). Fifty male patients treated surgically for NSCLC stages I-IIIa without neoadjuvant chemotherapy were included. Employing a multiparameter flow cytometry for CD1c, CD19, CD123 and CD303, we observed an accumulation of immature DCs in the tissues involved in the neoplasmatic process with the predominance of lymphoid/plasmacytoid over myeloid DCs. Moreover, in peripheral blood NSCLC patients had a significantly lower percentage of CD1c+ DCs than healthy donors. Our results suggest that NSCLC cells might hamper the maturation of DCs, thus escaping an efficient immune response.

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Copy and paste a formatted citation
Spandidos Publications style
Tabarkiewicz J, Rybojad P, Jablonka A and Rolinski J: CD1c+ and CD303+ dendritic cells in peripheral blood, lymph nodes and tumor tissue of patients with non-small cell lung cancer. Oncol Rep 19: 237-243, 2008.
APA
Tabarkiewicz, J., Rybojad, P., Jablonka, A., & Rolinski, J. (2008). CD1c+ and CD303+ dendritic cells in peripheral blood, lymph nodes and tumor tissue of patients with non-small cell lung cancer. Oncology Reports, 19, 237-243. https://doi.org/10.3892/or.19.1.237
MLA
Tabarkiewicz, J., Rybojad, P., Jablonka, A., Rolinski, J."CD1c+ and CD303+ dendritic cells in peripheral blood, lymph nodes and tumor tissue of patients with non-small cell lung cancer". Oncology Reports 19.1 (2008): 237-243.
Chicago
Tabarkiewicz, J., Rybojad, P., Jablonka, A., Rolinski, J."CD1c+ and CD303+ dendritic cells in peripheral blood, lymph nodes and tumor tissue of patients with non-small cell lung cancer". Oncology Reports 19, no. 1 (2008): 237-243. https://doi.org/10.3892/or.19.1.237
Copy and paste a formatted citation
x
Spandidos Publications style
Tabarkiewicz J, Rybojad P, Jablonka A and Rolinski J: CD1c+ and CD303+ dendritic cells in peripheral blood, lymph nodes and tumor tissue of patients with non-small cell lung cancer. Oncol Rep 19: 237-243, 2008.
APA
Tabarkiewicz, J., Rybojad, P., Jablonka, A., & Rolinski, J. (2008). CD1c+ and CD303+ dendritic cells in peripheral blood, lymph nodes and tumor tissue of patients with non-small cell lung cancer. Oncology Reports, 19, 237-243. https://doi.org/10.3892/or.19.1.237
MLA
Tabarkiewicz, J., Rybojad, P., Jablonka, A., Rolinski, J."CD1c+ and CD303+ dendritic cells in peripheral blood, lymph nodes and tumor tissue of patients with non-small cell lung cancer". Oncology Reports 19.1 (2008): 237-243.
Chicago
Tabarkiewicz, J., Rybojad, P., Jablonka, A., Rolinski, J."CD1c+ and CD303+ dendritic cells in peripheral blood, lymph nodes and tumor tissue of patients with non-small cell lung cancer". Oncology Reports 19, no. 1 (2008): 237-243. https://doi.org/10.3892/or.19.1.237
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