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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2008 Volume 19 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Protective effects of resveratrol on UVB-irradiated HaCaT cells through attenuation of the caspase pathway

  • Authors:
    • Kun Park
    • Ji-Hye Lee
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Eulji Hospital, Seoul 139-711, Korea. derma@chol.com
  • Pages: 413-417
    |
    Published online on: February 1, 2008
       https://doi.org/10.3892/or.19.2.413
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Abstract

Resveratrol, a polyphenol present in grapes and red wine, exerts wide biological properties including antioxidant, chemoprevention and cardioprotective effects. It was recently reported that resveratrol attenuates the oxidative DNA damage in neuronal cells. However, whether resveratrol attenuates the UVB-induced cell death in skin still remains largely unknown. In this study, to confirm the photoprotection properties of resveratrol, we investigated the effect of the pretreatment of resveratrol on UVB-treated HaCaT cells and molecular mechanisms concerning apoptotic pathways. Our data showed that HaCaT cells markedly decreased cell proliferation rates after UVB irradiation. Notably, the pretreatment of resveratrol on UVB irradiation resulted in an increase in cell survival which concomitantly reduced the reactive oxygen species production. Furthermore, the activation of caspase-3 and -8 was partially decreased in resveratrol-pretreated HaCaT cells, implying that the attenuation of caspase-3 and -8 activation is involved in cell survival after UVB irradiation. Thus, our data indicate that resveratrol may be a promising photoprotection agent, used in sunscreen products, to reduce cell death in UV-damaged skin.

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Copy and paste a formatted citation
Spandidos Publications style
Park K and Lee J: Protective effects of resveratrol on UVB-irradiated HaCaT cells through attenuation of the caspase pathway. Oncol Rep 19: 413-417, 2008.
APA
Park, K., & Lee, J. (2008). Protective effects of resveratrol on UVB-irradiated HaCaT cells through attenuation of the caspase pathway. Oncology Reports, 19, 413-417. https://doi.org/10.3892/or.19.2.413
MLA
Park, K., Lee, J."Protective effects of resveratrol on UVB-irradiated HaCaT cells through attenuation of the caspase pathway". Oncology Reports 19.2 (2008): 413-417.
Chicago
Park, K., Lee, J."Protective effects of resveratrol on UVB-irradiated HaCaT cells through attenuation of the caspase pathway". Oncology Reports 19, no. 2 (2008): 413-417. https://doi.org/10.3892/or.19.2.413
Copy and paste a formatted citation
x
Spandidos Publications style
Park K and Lee J: Protective effects of resveratrol on UVB-irradiated HaCaT cells through attenuation of the caspase pathway. Oncol Rep 19: 413-417, 2008.
APA
Park, K., & Lee, J. (2008). Protective effects of resveratrol on UVB-irradiated HaCaT cells through attenuation of the caspase pathway. Oncology Reports, 19, 413-417. https://doi.org/10.3892/or.19.2.413
MLA
Park, K., Lee, J."Protective effects of resveratrol on UVB-irradiated HaCaT cells through attenuation of the caspase pathway". Oncology Reports 19.2 (2008): 413-417.
Chicago
Park, K., Lee, J."Protective effects of resveratrol on UVB-irradiated HaCaT cells through attenuation of the caspase pathway". Oncology Reports 19, no. 2 (2008): 413-417. https://doi.org/10.3892/or.19.2.413
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