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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2008 Volume 19 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2008 Volume 19 Issue 3

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Article

Breast carcinomas expressing basal markers have poor clinical outcome regardless of estrogen receptor status

  • Authors:
    • Bong Kyung Shin
    • Youngseok Lee
    • Jung Bok Lee
    • Han Kyeom Kim
    • Jae Bok Lee
    • Su Jin Cho
    • Aeree Kim

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Korea University Guro Hospital, Seoul 152-703, Korea
  • Pages: 617-625
    |
    Published online on: March 1, 2008
       https://doi.org/10.3892/or.19.3.617
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Abstract

To evaluate the clinical significance of gene expression-based classification and define the characteristic features of the new basal-like subtype, invasive breast carcinomas were divided into ER, HER2, basal-like and null subtypes by immunohistochemical analysis. A total of 401 invasive breast carcinomas were submitted to tissue microarray and stained with ER, HER2, EGFR, c-KIT and cytokeratin (CK) 5/6. The basal-like tumors, defined as positive for one or more basal markers but negative for both ER and HER2, comprised 18.5%. They were larger (p=0.041), showed higher grade (p<0.001), and more frequently expressed p53 (p=0.003). Expression of the basal marker itself showed negative prognostic effect, particularly in node-positive group. Even ER-positive patients had far shorter disease-free survival (DFS) when the tumor coexpressed one or more basal marker (p<0.001). Discrimination of basal-like subtype or tumors positive for basal markers may be clinically significant also in the treatment and prognosis of breast carcinomas.

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Copy and paste a formatted citation
Spandidos Publications style
Shin BK, Lee Y, Lee JB, Kim HK, Lee JB, Cho SJ and Kim A: Breast carcinomas expressing basal markers have poor clinical outcome regardless of estrogen receptor status. Oncol Rep 19: 617-625, 2008.
APA
Shin, B.K., Lee, Y., Lee, J.B., Kim, H.K., Lee, J.B., Cho, S.J., & Kim, A. (2008). Breast carcinomas expressing basal markers have poor clinical outcome regardless of estrogen receptor status. Oncology Reports, 19, 617-625. https://doi.org/10.3892/or.19.3.617
MLA
Shin, B. K., Lee, Y., Lee, J. B., Kim, H. K., Lee, J. B., Cho, S. J., Kim, A."Breast carcinomas expressing basal markers have poor clinical outcome regardless of estrogen receptor status". Oncology Reports 19.3 (2008): 617-625.
Chicago
Shin, B. K., Lee, Y., Lee, J. B., Kim, H. K., Lee, J. B., Cho, S. J., Kim, A."Breast carcinomas expressing basal markers have poor clinical outcome regardless of estrogen receptor status". Oncology Reports 19, no. 3 (2008): 617-625. https://doi.org/10.3892/or.19.3.617
Copy and paste a formatted citation
x
Spandidos Publications style
Shin BK, Lee Y, Lee JB, Kim HK, Lee JB, Cho SJ and Kim A: Breast carcinomas expressing basal markers have poor clinical outcome regardless of estrogen receptor status. Oncol Rep 19: 617-625, 2008.
APA
Shin, B.K., Lee, Y., Lee, J.B., Kim, H.K., Lee, J.B., Cho, S.J., & Kim, A. (2008). Breast carcinomas expressing basal markers have poor clinical outcome regardless of estrogen receptor status. Oncology Reports, 19, 617-625. https://doi.org/10.3892/or.19.3.617
MLA
Shin, B. K., Lee, Y., Lee, J. B., Kim, H. K., Lee, J. B., Cho, S. J., Kim, A."Breast carcinomas expressing basal markers have poor clinical outcome regardless of estrogen receptor status". Oncology Reports 19.3 (2008): 617-625.
Chicago
Shin, B. K., Lee, Y., Lee, J. B., Kim, H. K., Lee, J. B., Cho, S. J., Kim, A."Breast carcinomas expressing basal markers have poor clinical outcome regardless of estrogen receptor status". Oncology Reports 19, no. 3 (2008): 617-625. https://doi.org/10.3892/or.19.3.617
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