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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2008 Volume 19 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Overexpression of connexin 26 in carcinoma of the pancreas

  • Authors:
    • Naganori Kyo
    • Hirofumi Yamamoto
    • Yutaka Takeda
    • Koji Ezumi
    • Chew Yee Ngan
    • Motokazu Terayama
    • Masakazu Miyake
    • Ichiro Takemasa
    • Masataka Ikeda
    • Yuichiro Doki
    • Keizo Dono
    • Mitsugu Sekimoto
    • Hiroshi Nojima
    • Morito Monden

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
  • Pages: 627-631
    |
    Published online on: March 1, 2008
       https://doi.org/10.3892/or.19.3.627
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Abstract

Contrary to the previously purported role of gap junction (GJ) associated-protein connexin 26 (Cx26) as a tumor suppressor, increased expression of Cx26 has recently been demonstrated in several human malignancies. Surprisingly, this high expression is reportedly related to poor prognosis in squamous cell lung carcinoma and breast cancer. In this study, we examined levels of Cx26 in various human gastrointestinal (GI) carcinomas, with a focus on pancreatic carcinomas, using immunohistochemistry. Many GI carcinomas displayed abundant Cx26 expression, predominantly in the cytoplasm. Cx26 was detected in 5/8 gastric cancers (62.5%), 6/8 squamous cell carcinomas of the esophagus (75.0%), 7/8 pancreatic cancers (87.5%) and 7/8 colon cancer cases (87.5%). However, Cx26 expression was not present in hepatocellular carcinoma (HCC, 0/8). Extensive immunohistochemical examination was performed on pancreatic carcinomas, revealing strong expression of Cx26 protein in 30/43 cases (70%), weak expression in 6/43 (14%) and no expression in 7/43 (16%). The present study demonstrated up-regulated Cx26 expression in a considerable percentage of GI carcinomas, with the exception of HCC. Our findings suggest that Cx26 may be involved in some of the malignant processes of GI cancers, and especially in pancreatic carcinomas.

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Copy and paste a formatted citation
Spandidos Publications style
Kyo N, Yamamoto H, Takeda Y, Ezumi K, Ngan CY, Terayama M, Miyake M, Takemasa I, Ikeda M, Doki Y, Doki Y, et al: Overexpression of connexin 26 in carcinoma of the pancreas. Oncol Rep 19: 627-631, 2008.
APA
Kyo, N., Yamamoto, H., Takeda, Y., Ezumi, K., Ngan, C.Y., Terayama, M. ... Monden, M. (2008). Overexpression of connexin 26 in carcinoma of the pancreas. Oncology Reports, 19, 627-631. https://doi.org/10.3892/or.19.3.627
MLA
Kyo, N., Yamamoto, H., Takeda, Y., Ezumi, K., Ngan, C. Y., Terayama, M., Miyake, M., Takemasa, I., Ikeda, M., Doki, Y., Dono, K., Sekimoto, M., Nojima, H., Monden, M."Overexpression of connexin 26 in carcinoma of the pancreas". Oncology Reports 19.3 (2008): 627-631.
Chicago
Kyo, N., Yamamoto, H., Takeda, Y., Ezumi, K., Ngan, C. Y., Terayama, M., Miyake, M., Takemasa, I., Ikeda, M., Doki, Y., Dono, K., Sekimoto, M., Nojima, H., Monden, M."Overexpression of connexin 26 in carcinoma of the pancreas". Oncology Reports 19, no. 3 (2008): 627-631. https://doi.org/10.3892/or.19.3.627
Copy and paste a formatted citation
x
Spandidos Publications style
Kyo N, Yamamoto H, Takeda Y, Ezumi K, Ngan CY, Terayama M, Miyake M, Takemasa I, Ikeda M, Doki Y, Doki Y, et al: Overexpression of connexin 26 in carcinoma of the pancreas. Oncol Rep 19: 627-631, 2008.
APA
Kyo, N., Yamamoto, H., Takeda, Y., Ezumi, K., Ngan, C.Y., Terayama, M. ... Monden, M. (2008). Overexpression of connexin 26 in carcinoma of the pancreas. Oncology Reports, 19, 627-631. https://doi.org/10.3892/or.19.3.627
MLA
Kyo, N., Yamamoto, H., Takeda, Y., Ezumi, K., Ngan, C. Y., Terayama, M., Miyake, M., Takemasa, I., Ikeda, M., Doki, Y., Dono, K., Sekimoto, M., Nojima, H., Monden, M."Overexpression of connexin 26 in carcinoma of the pancreas". Oncology Reports 19.3 (2008): 627-631.
Chicago
Kyo, N., Yamamoto, H., Takeda, Y., Ezumi, K., Ngan, C. Y., Terayama, M., Miyake, M., Takemasa, I., Ikeda, M., Doki, Y., Dono, K., Sekimoto, M., Nojima, H., Monden, M."Overexpression of connexin 26 in carcinoma of the pancreas". Oncology Reports 19, no. 3 (2008): 627-631. https://doi.org/10.3892/or.19.3.627
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