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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2008 Volume 19 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Inhibition of DLC-1 gene expression by RNA interference in the colon cancer LoVo cell line

  • Authors:
    • Yueling Jin
    • Xiaoqiang Tian
    • Yanfang Shang
    • Peiling Huang

  • View Affiliations / Copyright

    Affiliations: Department of Clinical Medicine, School of Clinical Medicine, Southeast University, Nanjing 210009, P.R. China
  • Pages: 669-674
    |
    Published online on: March 1, 2008
       https://doi.org/10.3892/or.19.3.669
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Abstract

DLC-1 (deleted in liver cancer-1) is a potential tumor suppressor gene, which is inactive in liver carcinogenesis. To observe the effects of DLC-1 gene expression on cell proliferation and migration in the human colon cancer cell line, RNAi Lipo-recombinant of the DLC-1 gene (pGCsil-DLC-1) was constructed and transduced into LoVo cells which are positive for DLC-1 gene expression. Results showed that the RNAi recombinant effectively inhibited the expression of the DLC-1 gene in LoVo cells. Additionally, our data showed decreased DLC-1 gene expression which resulted in the promotion of LoVo cell proliferation. Flow cytometry in cell cycle detection further indicated that the DLC-1 gene induced cell cycle arrest at G2/M and a cell migration assay confirmed that the knocking down of DLC-1 gene expression promotes LoVo cell migration. Our observations suggest that the DLC-1 gene is associated with LoVo cell proliferation, migration and cell cycle distribution. DLC-1 is a potential suppressor gene in the colon cancer LoVo cell line and may play an important role in colon cancer mechanisms.

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Copy and paste a formatted citation
Spandidos Publications style
Jin Y, Tian X, Shang Y and Huang P: Inhibition of DLC-1 gene expression by RNA interference in the colon cancer LoVo cell line. Oncol Rep 19: 669-674, 2008.
APA
Jin, Y., Tian, X., Shang, Y., & Huang, P. (2008). Inhibition of DLC-1 gene expression by RNA interference in the colon cancer LoVo cell line. Oncology Reports, 19, 669-674. https://doi.org/10.3892/or.19.3.669
MLA
Jin, Y., Tian, X., Shang, Y., Huang, P."Inhibition of DLC-1 gene expression by RNA interference in the colon cancer LoVo cell line". Oncology Reports 19.3 (2008): 669-674.
Chicago
Jin, Y., Tian, X., Shang, Y., Huang, P."Inhibition of DLC-1 gene expression by RNA interference in the colon cancer LoVo cell line". Oncology Reports 19, no. 3 (2008): 669-674. https://doi.org/10.3892/or.19.3.669
Copy and paste a formatted citation
x
Spandidos Publications style
Jin Y, Tian X, Shang Y and Huang P: Inhibition of DLC-1 gene expression by RNA interference in the colon cancer LoVo cell line. Oncol Rep 19: 669-674, 2008.
APA
Jin, Y., Tian, X., Shang, Y., & Huang, P. (2008). Inhibition of DLC-1 gene expression by RNA interference in the colon cancer LoVo cell line. Oncology Reports, 19, 669-674. https://doi.org/10.3892/or.19.3.669
MLA
Jin, Y., Tian, X., Shang, Y., Huang, P."Inhibition of DLC-1 gene expression by RNA interference in the colon cancer LoVo cell line". Oncology Reports 19.3 (2008): 669-674.
Chicago
Jin, Y., Tian, X., Shang, Y., Huang, P."Inhibition of DLC-1 gene expression by RNA interference in the colon cancer LoVo cell line". Oncology Reports 19, no. 3 (2008): 669-674. https://doi.org/10.3892/or.19.3.669
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