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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2008 Volume 19 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression

  • Authors:
    • Youichirou Matsuzaki
    • Makoto Koyama
    • Toshiaki Hitomi
    • Tomoya Yokota
    • Mayumi Kawanaka
    • Akiyoshi Nishikawa
    • Doris Germain
    • Toshiyuki Sakai

  • View Affiliations / Copyright

    Affiliations: Department of Molecular-Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
  • Pages: 721-727
    |
    Published online on: March 1, 2008
       https://doi.org/10.3892/or.19.3.721
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Abstract

Arctiin is a major lignan constituent of Arctium lappa and has anti-cancer properties in animal models. It was recently reported that arctiin induces growth inhibition in human prostate cancer PC-3 cells. However, the growth inhibitory mechanism of arctiin remains unknown. Herein we report that arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. We also show that the growth inhibition caused by arctiin is associated with the down-regulation of cyclin D1 protein expression. Furthermore, the arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer. Depletion of the cyclin D1 protein using small interfering RNA-rendered human breast cancer MCF-7 cells insensitive to the growth inhibitory effects of arctiin, implicates cyclin D1 as an important target of arctiin. Taken together, these results suggest that arctiin down-regulates cyclin D1 protein expression and that this at least partially contributes to the anti-proliferative effect of arctiin.

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Copy and paste a formatted citation
Spandidos Publications style
Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D and Sakai T: Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep 19: 721-727, 2008.
APA
Matsuzaki, Y., Koyama, M., Hitomi, T., Yokota, T., Kawanaka, M., Nishikawa, A. ... Sakai, T. (2008). Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncology Reports, 19, 721-727. https://doi.org/10.3892/or.19.3.721
MLA
Matsuzaki, Y., Koyama, M., Hitomi, T., Yokota, T., Kawanaka, M., Nishikawa, A., Germain, D., Sakai, T."Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression". Oncology Reports 19.3 (2008): 721-727.
Chicago
Matsuzaki, Y., Koyama, M., Hitomi, T., Yokota, T., Kawanaka, M., Nishikawa, A., Germain, D., Sakai, T."Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression". Oncology Reports 19, no. 3 (2008): 721-727. https://doi.org/10.3892/or.19.3.721
Copy and paste a formatted citation
x
Spandidos Publications style
Matsuzaki Y, Koyama M, Hitomi T, Yokota T, Kawanaka M, Nishikawa A, Germain D and Sakai T: Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep 19: 721-727, 2008.
APA
Matsuzaki, Y., Koyama, M., Hitomi, T., Yokota, T., Kawanaka, M., Nishikawa, A. ... Sakai, T. (2008). Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncology Reports, 19, 721-727. https://doi.org/10.3892/or.19.3.721
MLA
Matsuzaki, Y., Koyama, M., Hitomi, T., Yokota, T., Kawanaka, M., Nishikawa, A., Germain, D., Sakai, T."Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression". Oncology Reports 19.3 (2008): 721-727.
Chicago
Matsuzaki, Y., Koyama, M., Hitomi, T., Yokota, T., Kawanaka, M., Nishikawa, A., Germain, D., Sakai, T."Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression". Oncology Reports 19, no. 3 (2008): 721-727. https://doi.org/10.3892/or.19.3.721
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