Prognostic impact of p53 Pro72 homozygous genotype in non-small cell lung cancer patients

  • Authors:
    • Laura Boldrini
    • Silvia Gisfredi
    • Silvia Ursino
    • Marco Lucchi
    • Giordana Greco
    • Alfredo Mussi
    • Gabriella Fontanini
  • View Affiliations

  • Published online on: March 1, 2008     https://doi.org/10.3892/or.19.3.771
  • Pages: 771-773
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Abstract

Mutations of the p53 gene represent the most common genetic alterations in human cancer. Several reports have focused on p53 polymorphisms as risk factors in lung cancer, in particular at codon 72 of exon 4, encoding either an arginine (Arg72R) or a proline (Pro72P) amino acid. Polymorphisms at codon 72 of the p53 gene were determined using a PCR-RFLP-based method. We analysed the relationship of this polymorphism to patient survival in 121 non-small cell lung cancer (NSCLC) cases. Interestingly, the 72P homozygous NSCLC patients often presented high-grade tumours and had significantly poorer survival rates than patients with R72 homozygotes or heterozygotes. Our results may help clarify discrepancies in the literature concerning the prognostic role of p53 codon 72 variants.

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March 2008
Volume 19 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Boldrini L, Gisfredi S, Ursino S, Lucchi M, Greco G, Mussi A and Fontanini G: Prognostic impact of p53 Pro72 homozygous genotype in non-small cell lung cancer patients. Oncol Rep 19: 771-773, 2008
APA
Boldrini, L., Gisfredi, S., Ursino, S., Lucchi, M., Greco, G., Mussi, A., & Fontanini, G. (2008). Prognostic impact of p53 Pro72 homozygous genotype in non-small cell lung cancer patients. Oncology Reports, 19, 771-773. https://doi.org/10.3892/or.19.3.771
MLA
Boldrini, L., Gisfredi, S., Ursino, S., Lucchi, M., Greco, G., Mussi, A., Fontanini, G."Prognostic impact of p53 Pro72 homozygous genotype in non-small cell lung cancer patients". Oncology Reports 19.3 (2008): 771-773.
Chicago
Boldrini, L., Gisfredi, S., Ursino, S., Lucchi, M., Greco, G., Mussi, A., Fontanini, G."Prognostic impact of p53 Pro72 homozygous genotype in non-small cell lung cancer patients". Oncology Reports 19, no. 3 (2008): 771-773. https://doi.org/10.3892/or.19.3.771