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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2008 Volume 19 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization

  • Authors:
    • Xiaohong Lu
    • Peter K. Vogt
    • Dale L. Boger
    • John Lunec

  • View Affiliations / Copyright

    Affiliations: Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
  • Pages: 825-830
    |
    Published online on: March 1, 2008
       https://doi.org/10.3892/or.19.3.825
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Abstract

Inhibition of MYC/MAX dimerization by a small-molecule antagonist (IIA6B17) has been shown to interfere with MYC-induced transformation of chick embryo fibroblasts, suggesting that the functional inhibitors of the MYC family of oncoproteins have potential as therapeutic agents. In the present study, a functional MYC reporter gene assay has been developed, using a luciferase gene construct under the control of the ornithine decarboxylase (ODC) gene promoter. This luciferase gene construct has been stably transfected into the MYCN amplified neuroblastoma cell line (NGP) and MYCC-overexpressed neuroepithelioma cell line (NB100). After exposure of the cell lines to IIA6B17 for 24 h, a significant reduction of luciferase activity was only observed in the NB100 cells, with IC50 values of ≈28±9 µM, indicating that IIA6B17 has cell line-specific activity which may be selective for individual members of the MYC family.

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Copy and paste a formatted citation
Spandidos Publications style
Lu X, Vogt PK, Boger DL and Lunec J: Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization. Oncol Rep 19: 825-830, 2008.
APA
Lu, X., Vogt, P.K., Boger, D.L., & Lunec, J. (2008). Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization. Oncology Reports, 19, 825-830. https://doi.org/10.3892/or.19.3.825
MLA
Lu, X., Vogt, P. K., Boger, D. L., Lunec, J."Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization". Oncology Reports 19.3 (2008): 825-830.
Chicago
Lu, X., Vogt, P. K., Boger, D. L., Lunec, J."Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization". Oncology Reports 19, no. 3 (2008): 825-830. https://doi.org/10.3892/or.19.3.825
Copy and paste a formatted citation
x
Spandidos Publications style
Lu X, Vogt PK, Boger DL and Lunec J: Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization. Oncol Rep 19: 825-830, 2008.
APA
Lu, X., Vogt, P.K., Boger, D.L., & Lunec, J. (2008). Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization. Oncology Reports, 19, 825-830. https://doi.org/10.3892/or.19.3.825
MLA
Lu, X., Vogt, P. K., Boger, D. L., Lunec, J."Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization". Oncology Reports 19.3 (2008): 825-830.
Chicago
Lu, X., Vogt, P. K., Boger, D. L., Lunec, J."Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization". Oncology Reports 19, no. 3 (2008): 825-830. https://doi.org/10.3892/or.19.3.825
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