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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2008 Volume 19 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Generation of multidrug resistant lymphoma cell lines stably expressing P-glycoprotein

  • Authors:
    • Iliodora Pop
    • Laurentiu Pop
    • Ellen S. Vitetta
    • Maria-Ana Ghetie

  • View Affiliations / Copyright

    Affiliations: The Cancer Immunobiology Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-8576, USA
  • Pages: 889-895
    |
    Published online on: April 1, 2008
       https://doi.org/10.3892/or.19.4.889
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Abstract

The objective of this study was to generate new P-glycoprotein (P-gp)-expressing multidrug resistant (MDR) cell lines by drug selection. Since our previous studies have been carried out with cells infected with a P-gp-containing vector, it was important to confirm our findings in cells generated by drug selection. In this report, we describe three B-lymphoma cell lines which became drug-resistant by stepwise exposure to vincristine (VCR): Raji cells resistant to 18 nM VCR (R18V), Namalwa cells resistant to 21 nM VCR (N21V) and DHL-4 cells resistant to 12 nM VCR (DHL-4/12V). Cells overexpressed P-gp and continued to express CD19, CD20 and CD22, all of which are targets for monoclonal antibody (MAb) therapy. The P-gp pump in these new cells was functional as determined by the efflux of Rhodamine 123 and DIOC2, and the three cell lines were resistant to several chemotherapeutic drugs. We further determined that their P-gp phenotype was stable in xenografted SCID mice and that the tumors were also resistant to chemotherapy. We will now use these new MDR cells to determine whether monoclonal antibodies against CD19 and -20 can reverse P-gp, as we previously demonstrated using Namalwa cells infected with a human mdr1 gene-containing retrovirus.

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Copy and paste a formatted citation
Spandidos Publications style
Pop I, Pop L, Vitetta ES and Ghetie M: Generation of multidrug resistant lymphoma cell lines stably expressing P-glycoprotein. Oncol Rep 19: 889-895, 2008.
APA
Pop, I., Pop, L., Vitetta, E.S., & Ghetie, M. (2008). Generation of multidrug resistant lymphoma cell lines stably expressing P-glycoprotein. Oncology Reports, 19, 889-895. https://doi.org/10.3892/or.19.4.889
MLA
Pop, I., Pop, L., Vitetta, E. S., Ghetie, M."Generation of multidrug resistant lymphoma cell lines stably expressing P-glycoprotein". Oncology Reports 19.4 (2008): 889-895.
Chicago
Pop, I., Pop, L., Vitetta, E. S., Ghetie, M."Generation of multidrug resistant lymphoma cell lines stably expressing P-glycoprotein". Oncology Reports 19, no. 4 (2008): 889-895. https://doi.org/10.3892/or.19.4.889
Copy and paste a formatted citation
x
Spandidos Publications style
Pop I, Pop L, Vitetta ES and Ghetie M: Generation of multidrug resistant lymphoma cell lines stably expressing P-glycoprotein. Oncol Rep 19: 889-895, 2008.
APA
Pop, I., Pop, L., Vitetta, E.S., & Ghetie, M. (2008). Generation of multidrug resistant lymphoma cell lines stably expressing P-glycoprotein. Oncology Reports, 19, 889-895. https://doi.org/10.3892/or.19.4.889
MLA
Pop, I., Pop, L., Vitetta, E. S., Ghetie, M."Generation of multidrug resistant lymphoma cell lines stably expressing P-glycoprotein". Oncology Reports 19.4 (2008): 889-895.
Chicago
Pop, I., Pop, L., Vitetta, E. S., Ghetie, M."Generation of multidrug resistant lymphoma cell lines stably expressing P-glycoprotein". Oncology Reports 19, no. 4 (2008): 889-895. https://doi.org/10.3892/or.19.4.889
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