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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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April 2008 Volume 19 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model

  • Authors:
    • Marie Van de Putte
    • Huaijun Wang
    • Feng Chen
    • Peter A.M. De Witte
    • Yicheng Ni

  • View Affiliations / Copyright

    Affiliations: Laboratory for Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, B-3000 Leuven, Belgium
  • Pages: 927-932
    |
    Published online on: April 1, 2008
       https://doi.org/10.3892/or.19.4.927
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Abstract

In this proof-of-principle study, the necrosis avid agent hypericin was investigated as a potential indicator for early therapeutic response following radiofrequency ablation (RFA) of murine liver tumors. Eight mice bearing intrahepatic RIF-1 tumors were intravenously injected with hypericin 1 h before or 24 h after RFA treatment. Mice were euthanized 24 h after hypericin injection and excised livers were investigated by means of fluoromacroscopic and fluoromicroscopic examinations in combination with conventional histomorphology. Significant differences in hypericin fluorescence were found in necrosis, viable tumor and normal liver tissue in a decreasing order: in necrosis, mean fluorescence densities were about 5 times higher than in viable tumor and approximately 12 times higher than in normal liver (p<0.05). Mean fluorescence densities were not significantly different when hypericin was injected 24 h after or 1 h before RFA treatment (p>0.05). As a conclusion, hypericin features the property to specifically enhance the imaging contrast between necrotic and viable tissues and to non-specifically distinguish viable tumor from normal liver. The results suggest that hypericin offers significant potential in the early assessment of response following necrosis-inducing antineoplastic treatments such as RFA.

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Copy and paste a formatted citation
Spandidos Publications style
Van de Putte M, Wang H, Chen F, De Witte PA and Ni Y: Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model. Oncol Rep 19: 927-932, 2008.
APA
Van de Putte, M., Wang, H., Chen, F., De Witte, P.A., & Ni, Y. (2008). Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model. Oncology Reports, 19, 927-932. https://doi.org/10.3892/or.19.4.927
MLA
Van de Putte, M., Wang, H., Chen, F., De Witte, P. A., Ni, Y."Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model". Oncology Reports 19.4 (2008): 927-932.
Chicago
Van de Putte, M., Wang, H., Chen, F., De Witte, P. A., Ni, Y."Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model". Oncology Reports 19, no. 4 (2008): 927-932. https://doi.org/10.3892/or.19.4.927
Copy and paste a formatted citation
x
Spandidos Publications style
Van de Putte M, Wang H, Chen F, De Witte PA and Ni Y: Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model. Oncol Rep 19: 927-932, 2008.
APA
Van de Putte, M., Wang, H., Chen, F., De Witte, P.A., & Ni, Y. (2008). Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model. Oncology Reports, 19, 927-932. https://doi.org/10.3892/or.19.4.927
MLA
Van de Putte, M., Wang, H., Chen, F., De Witte, P. A., Ni, Y."Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model". Oncology Reports 19.4 (2008): 927-932.
Chicago
Van de Putte, M., Wang, H., Chen, F., De Witte, P. A., Ni, Y."Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model". Oncology Reports 19, no. 4 (2008): 927-932. https://doi.org/10.3892/or.19.4.927
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