Up-regulation of stromal cell-derived factor-1α and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma

  • Authors:
    • Masayuki Taki
    • Koichiro Higashikawa
    • Shingo Yoneda
    • Shigehiro Ono
    • Hideo Shigeishi
    • Masaru Nagayama
    • Nobuyuki Kamata
  • View Affiliations

  • Published online on: April 1, 2008     https://doi.org/10.3892/or.19.4.993
  • Pages: 993-998
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Abstract

Stromal cell-derived factor 1α (SDF-1α) and its receptor CXCR4 have been implicated in the tumorigenesis, proliferation, and lymph node metastasis of cancer. Here, we report that highly invasive squamous cell carcinoma (SCC) cells with a spindle cell morphology show a strong expression of both SDF-1α and CXCR4. CXCR4 expression and cell migratory activity were further up-regulated by treatment with SDF-1α or TGF-β1 in these cells. When epithelial-mesenchymal transition (EMT) was induced by Snail over-expression in SCC cells with an epithelial phenotype, an increased expression of SDF-1α was observed. Furthermore, SDF-1α and TGF-β1 up-regulated the expression of CXCR4 and cell migratory activity in these cells. These results indicate that SDF-1α and CXCR4 expressions are possible markers of highly-invasive SCC and regulated by EMT.

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April 2008
Volume 19 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Taki M, Higashikawa K, Yoneda S, Ono S, Shigeishi H, Nagayama M and Kamata N: Up-regulation of stromal cell-derived factor-1α and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma. Oncol Rep 19: 993-998, 2008.
APA
Taki, M., Higashikawa, K., Yoneda, S., Ono, S., Shigeishi, H., Nagayama, M., & Kamata, N. (2008). Up-regulation of stromal cell-derived factor-1α and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma. Oncology Reports, 19, 993-998. https://doi.org/10.3892/or.19.4.993
MLA
Taki, M., Higashikawa, K., Yoneda, S., Ono, S., Shigeishi, H., Nagayama, M., Kamata, N."Up-regulation of stromal cell-derived factor-1α and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma". Oncology Reports 19.4 (2008): 993-998.
Chicago
Taki, M., Higashikawa, K., Yoneda, S., Ono, S., Shigeishi, H., Nagayama, M., Kamata, N."Up-regulation of stromal cell-derived factor-1α and its receptor CXCR4 expression accompanied with epithelial-mesenchymal transition in human oral squamous cell carcinoma". Oncology Reports 19, no. 4 (2008): 993-998. https://doi.org/10.3892/or.19.4.993